Purpose. The purpose of the research was to study the clinical features of the course of ankylosing spondylitis: functional activity, dynamics of inflammation markers and other disorders in patients in the post COVID period. Materials and methods. The research included 50 patients with ankylosing spondylitis who had undergone COVID-19 and 20 patients who did not have a history of COVID-19. All patients underwent an assessment on the BASDAI, BASFI, ASDAS, VAS (pain) scales, as well as biochemical, immunological, instrumental (X-ray, MRI of the pelvis and spine, ECG, ECHOCG) investigations. Results. High indices of Lansbury, BASDAI, BASFI, ASDAS and VAS scales were noted in the main group than in the control, which indicates the severity of functional disorders. In the majority of patients of main group bilateral sacroiliitis, enthesopathies, and disorders of cardiovascular function (disturbances of myocardial excitability, electrical conduction, damage of valves, an increase size of chambers) were revealed. Conclusions. A direct negative effect of the postponed coronavirus infection on the course of ankylosing spondylitis has been established: the resistance of the disease activity, more pronounced violations of functional activity, as well as disorders of the cardiovascular system.
1. Haubner, B., Tanner, F. C., Ruschitzka, F., Flammer, A. J., & Matthias, P. N. Endothelial dysfunction in COVID-19: current findings and therapeutic implications. //Atherosclerosis, 314(2020), 58–62. 2. Azevedo, R. B., Botelho, B. G., Hollanda, J. V. G. de, Ferreira, L. V. L., Junqueira de Andrade, L. Z., Oei, S. S. M. L., Mello, T. de S., & Muxfeldt, E. S. (2021). Covid-19 and the cardiovascular system: a comprehensive review. //Journal of Human Hypertension, 35(1), 4–11 3. D’Antiga, L. (2020). Coronaviruses and Immunosuppressed Patients: The Facts During the Third Epidemic. //Liver Transplantation, 26(6), 832–834 4. Coskun Benlidayi, I., Kurtaran, B., Tirasci, E., & Guzel, R. (2020). Coronavirus disease 2019 (COVID-19) in a patient with ankylosing spondylitis treated with secukinumab: a case-based review. //Rheumatology International, 40(10), 1707–1716 5. Uhrin, Z., Kuzis, S., & Ward, M. M. (n.d.). Exercise and Changes in Health Status in Patients With Ankylosing Spondylitis. Retrieved August 22, 2021 6. Liew, J. W., Castillo, M., Zaccagnino, E., Katz, P., Haroon, N., & Gensler, L. S. (2020). Patient-reported Disease Activity in an Axial Spondyloarthritis Cohort during the COVID-19 Pandemic. 2(9), 533–539. 7. Iegudina, I. D., Syniachenko, O. V., Ermolaeva, M. V., Chernyshova, O. E., Polesovа, T. R., & Khaniukov, A. A. (2017). Vascular rheological properties of the blood in ankylosing spondylitis. //Trauma, 18(1), 80–86. 8. Haubner, B., Tanner, F. C., Ruschitzka, F., Flammer, A. J., & Matthias, P. N. (2020). Endothelial dysfunction in COVID-19: current findings and therapeutic implications. //Atherosclerosis, 314(2020), 58–62. 9. Roux, C. H., Brocq, O., Gerald, F., Pradier, C., & Bailly, L. (2020). Clinical impact of COVID-19 on a French population of spondyloarthritis patients. // Clinical Rheumatology (Vol. 39, Issue 11, pp. 3185–3187). Springer Science and Business Media Deutschland GmbH 10. Łosińska, K., Korkosz, M., & Kwaśny-Krochin, B. (2019). Endothelial dysfunction in patients with ankylosing spondylitis. //Reumatologia, 57(2), 100–105 11. Abdurakhmanova N.M., Akhmedov Kh.S. " Kliniko- funksionalnie osobennosti techeniya ankiloziruyushego spondiloartrita u bolnix, perenesshix COVID-19 ". //Nauchno- practicheskiy jurnal “Infeksiya, immunitet I farmakologiya” (4/2021), p. 20-23 12. Rakhimova, M. B., Kh S. Akhmedov, and Y. A. Turaev. "Endothelial dysfunction as a link in the pathogenesis of ankylosing spondylitis against the background of a new coronavirus infection." // ACADEMICIA: An International Multidisciplinary Research Journal 11.3 (2021): 2493-2498.
Rakhimova, Madina B. and Akhmedov, Khalmurad S.
"THE IMPACT OF SEQUELAE OF COVID-19 ON THE COURSE OF ANKYLOSING SPONDYLITIS,"
Central Asian Journal of Medicine: Vol. 2021
, Article 7.
Available at: https://uzjournals.edu.uz/tma/vol2021/iss4/7