Central Asian Journal of Medicine


Currently, there is a steady trend towards an increase in the number of patients with gallstone disease and metabolic syndrome. The two diseases share several risk factors in common, including age, gender, being overweight, and impaired lipid and glucose metabolism. In the pathogenesis, the development of gallstone disease and metabolic syndrome plays an important role in the violation of lipid metabolism. Lipid metabolism disorders are primarily characterized by an increase in cholesterol and triglyceride levels in the blood. The primary cause of lipid metabolism disorders is hereditary - a genetic factor. Purpose of the study: To study the role of polymorphism rs1799883 of the FABP2 gene and rs1801282 of the PPARG2 gene in the pathogenesis of gallstone disease in combination with metabolic syndrome. Material and methods. The materials of our research work in the surgical departments of the Khorezm Regional Multidisciplinary Medical Center are based on clinical analysis and the results of diagnostics of patients with gallstone disease with metabolic syndrome and gallstone disease without metabolic disorders. Molecular genetic studies were carried out in the Department of Molecular Medicine and Cell Technologies of the Republican Specialized Scientific and Practical Medical Center of Hematology. Association analysis of the polymorphisms rs1799883 of the FABP2 gene and rs1801282 of the PPARG2 gene was carried out using a case-control model. Conclusion: Our results allow us to conclude that the homozygous Thr/Thr genotype plays an important role in the pathogenesis of nosological syntropy of gallstone disease and metabolic syndrome. The risk of developing gallstone disease with metabolic syndrome when carrying this genotypic variant of the FABP2 gene can significantly increase by more than 3.0 times. The homozygous Ala/Ala genotype indicates a protective effect in the formation of gallstone disease with a combination of metabolic syndrome. The rs1801282 polymorphism of the PPARG2 gene does not allow the use of this locus as a genetic marker for predicting the risk of metabolic syndrome in patients with gallstone disease .

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