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Central Asian Journal of Medicine

Abstract

In world medicine, the problem of cardiopulmonary comorbidity, including the development of thrombotic cardiovascular catastrophes against the background of chronic obstructive pulmonary disease (COPD), is becoming increasingly important. Endothelial dysfunction, developing as a result of changes in the underlying pathogenesis of COPD, can increase the predisposition to cardiovascular complications - thrombosis in this group of patients. The purpose. The aim of this study was to analyze the available scientific data on the possible role of endothelial dysfunction in the high incidence of thrombotic complications in COPD. Material and research methods. The research material was the open access scientific literature of the last 20 years. The study used the methods of retrospective analysis of literature data. Results. The results of the study provide argumentation for the role of endothelial dysfunction in patients with COPD. The role of multifactorial genesis of the development of endothelial dysfunction in COPD, mediated by such factors as long-term high activity of pro-inflammatory cytokines, the presence of a smoking factor, hyperlipidemia, chronic hypoxia, hyperhomocysteinemia, etc., is emphasized. Conclusion. The authors concluded that endothelial dysfunction in COPD is one of the fundamental elements of high thrombotic activity.

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References

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