Central Asian Journal of Medicine


We examined 62 people, including 51 patients with early stages of diabetic nephropathy (DN), against the background of type 2 diabetes mellitus (DM) at the age of 40 to 65 years, and 15 apparently healthy individuals. Disease duration ranged from 6 months to 3 years. The patients were divided into 3 groups: Group I - diabetics with normoalbuminuria, Group II - diabetics with microalbuminuria (MAU), Group III - with MAU and an increase in blood pressure to the upper limits of the norm (130 / 80-140 / 90 mm Hg). We studied such indicators as the glomerular filtration rate (GFR) by the radionuclide method; the size of the kidneys by ultrasound; UIA; the level of nitric oxide (NO) in daily urine; Intrarenal hemodynamic indexes - Doppler data PI, RI, Vmax. Analysis of the materials obtained in the course of the study allows us to say that with type 2 diabetes, the kidneys are actively affected already at the very beginning of the disease. The appearance of MAU or an increase in blood pressure to the upper limits of the norm in patients with diabetes mellitus 2 indicate an already advanced pathological process in the kidneys from the point of view of the possibility of its reverse development. Changes in the functional state of the kidneys take place already at the prealbuminuric stage of development of DN, and it is this stage that should be a "springboard" for an aggressive effect on hyperfiltration, renomegaly, and endothelial dysfunction that take place.

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