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Central Asian Journal of Medicine

Abstract

The presence of a relationship between polymorphism of the IL23R gene receptor (11209026) and the risk of developing rheumatoid arthritis in Uzbekistan was studied. The polymorphism of the IL23R gene receptor (11209026) was assessed by analyzing DNA samples by standard PCR. The results of a study to study the polymorphism of the IL23R gene receptor (11209026) in the general group of patients with RA and in the subgroup 1A of patients with articular RA showed the presence of statistically significant differences in the carriage of the A allele (14.1% versus 7.8%; χ2 = 4.46; P = 0.04; OR = 1.95; 95% CI: 1.05-3.62) and (15.5% versus 7.8%; χ2 = 5.43; P = 0.02; OR = 2.176; 95% CI: 1.131-4.185), respectively, as well as a clear tendency towards an increased risk of developing RA in carriers of the G / A genotype (22.7% versus 15.6%; χ2 = 1.73; P = 0.19; OR = 1.58; 95% CI: 0.798-3.145) and (25.7% versus 15.6%; χ2 = 2.83; P = 0.09; OR = 1.87; 95% CI: 0.902-3.876), respectively. Therefore, allele A and genotype G / A can be considered as molecular genetic markers that increase the likelihood of developing articular RA.

First Page

47

Last Page

55

References

1. Aletaha D, Neogi T, Silman AJ, Funovits J, Felson DT, Bingham CO et al (2010) 2010 Rheumatoid arthritis classification criteria: an American College of Rheumatology/European League Against Rheumatism collaborative initiative. Arthritis Rheum 62(9):2569–2578. 2. Bogunia-Kubik K, Swierkot J, Malak A, et al. IL-17A, IL-17F and IL-23R gene polymorphisms in Polish patients with rheumatoid arthritis. Arch Immunol Ther Exp (Warsz). 2015;63:215–221.; 3. Castro-Santos P, Diaz-Pena R Genetics of rheumatoid arthritis: a new boost is needed in Latin American populations. Rev Bras Reumatol. 2016;56:171–177. 4. Du, J., Wang, X., Tan, G., Liang, Z., Zhang, Z., & Yu, H. (2019). Association between genetic polymorphisms of the interleukin 23 receptor gene and the risk of developing rheumatoid arthritis: An updated meta-analysis. Clinical immunology, 108250. doi:10.1016/j.clim.2019.108250. 5. Duvallet E, Semerano L, Assier E, Falgarone G, Boissier MC (2011) Interleukin-23: a key cytokine in inflammatory diseases. Ann Med 43:503–511. 6. Fatemeh SM, Aslani S, Mostafaei S, Jamshidi A, Riahi P, Mahmoudi M (2019) Are genetic variations in IL-21-IL-23R-IL-17A cytokine axis involved in a pathogenic pathway of rheumatoid arthritis? A Bayesian hierarchical meta-analysis. J Cell Physiol 234(10):17159–17171. 7. Hamdy G, Darweesh H, Khattab EA, Fawzy S, Fawzy E, Sheta M (2015) Evidence of association of interleukin-23 receptor gene polymorphisms with Egyptian rheumatoid arthritis patients. Hum Immunol 76:417–420. 8. Hazlett J, Stamp LK, Merriman T, Highton J, Hessian PA (2012) IL-23R rs11209026 polymorphism modulates IL-17A expression in patients with rheumatoid arthritis. Genes Immun 13(3):282–287. 9. Humphreys JH, Symmons DP. Post publication validation of the 2010 American College of Rheumatology/European League Against Rheumatism classification criteria for rheumatoid arthritis: where do we stand? Curr Opin Rheumatol.2012;25:157–63. 10. Koyun B, Ozalp E, Acet O, Erbaş O (2018) Current effective treatment methods for interleukin-23/T helper type 17 cells pathway in rheumatologic and autoimmune diseases. FNG & Demiroğlu Bilim Tıp Transplantasyon Dergisi 3(1–2):25–30. 11. Lubberts E (2015) The IL-23-IL-17 axis in inflammatory arthritis. Nat Rev Rheumatol 11(7):415–429. 12. Moens E, Brouwer M, Dimova T, et al. IL-23R and TCR signaling drives the generation of neonatal Vgamma9Vdelta2 T cells expressing high levels of cytotoxic mediators and producing IFN-gamma and IL-17. J Leukoc Biol. 2011;89:743–752. 13. Paradowska-Gorycka, A., Malinowski, D., Haladyj, E., Olesinska, M., Safranow, K., & Pawlik, A. (2018). Lack of association between rheumatoid arthritis and genetic variants rs10889677, rs11209026 and rs2201841 of IL-23R gene. Medicina Clínica. doi:10.1016/j.medcli.2017.11.029. 14. Ruyssen-Witrand A, Constantin A, Cambon-Thomsen A, Thomsen M (2012) New insights into the genetics of immune responses in rheumatoid arthritis. Tissue Antigens 80(2):105–118. 15. Song GG, Bae SC, Choi SJ, Ji JD, Lee YH (2012) Associations between interleukin-23 receptor polymorphisms and susceptibility to rheumatoid arthritis: a meta-analysis. Mol Biol Rep 39:10655–10663. 16. Soysal, E., Ulutaş, F., Tepeli, E. et al. IL-23R gene polymorphisms in rheumatoid arthritis. Rheumatol Int (2021). https://doi.org/10.1007/s00296-021-04881-9. 17. Szabo M, Safrany E, Pazar B, et al. Marked diversity of IL23R gene haplotype variants in rheumatoid arthritis comparing with Crohn's disease and ankylosing spondylitis. Mol Biol Rep. 2013;40:359–363. 18. Yuan N, Yu G, Liu D, Wang X, Zhao L (2019) An emerging role of interleukin-23 in rheumatoid arthritis. Immunopharmacol Immunotoxicol 41(2):185–191. 19. Zaky DS, El-Nahrery EM (2016) Role of interleukin-23 as a biomarker in rheumatoid arthritis patients and its correlation with disease activity. Int Immunopharmacol 31:105–108. 20. Zhai Y, Xu K, Huang F, Peng H, Feng CC, Zhu KK et al (2012) Association of interleukin 23 receptor gene polymorphisms (rs10489629, rs7517847) with rheumatoid arthritis in a European population: a meta-analysis. Mol Biol Rep 39:8987–8994. 21. Zou Q, Zhao Y, Wang Y, Fang Y, Liu Y (2019) Associations between IL-23R gene polymorphisms and the susceptibility of rheumatoid arthritis: a meta-analysis. Artif Cells Nanomed Biotechnol 47:951–956.

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