Central Asian Journal of Medicine


Chronic obstructive pulmonary disease (COPD) is one of the most common non-communicable diseases on the territory of the Republic of Uzbekistan. Thrombotic events are common cause of hospitalization and death in this category of patients. The purpose. To clarify the etiology of frequent thrombosis in patients with COPD, the authors studied the occurrence of the Asp919Gly (A / G) polymorphism of the MTR gene as a cause of hyperhomocysteinemia and the occurrence of high thrombotic risk states. Material and research methods. The study included 49 patients with III-IV stages of COPD. The DNA diagnostic methods were based on polymerase chain reaction (PCR). Results. In the course of the study, the authors did not establish associations between the occurrence of this polymorphism among patients with COPD and healthy volunteers, but when comparing the frequency of polymorphism among groups of patients with COPD with / without thrombosis in anamnesis, an association was established between the occurrence of the Asp919Gly (A / G) polymorphism of the MTR gene with thrombotic complications. Conclusion. The results obtained allow us to conclude that thrombotic events in patients with COPD may be associated with the development of hyperhomocysteinemia, which develops on the background of a decrease in the activity of the enzyme methionine synthase, which is a consequence of Asp919Gly polymorphisms of the MTR gene.

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