Central Asian Journal of Medicine


The purpose is to assess the influence of the level of the biomarker Galectin-3 in the blood on the clinical and functional state and hemodynamic parameters of patients with coronary artery disease complicated by CHF in Post-COVID 19 Period. Material and research methods. 70 patients with CHF against the background of stable coronary artery disease were examined: 36 patients with coronary artery disease / CHF who had undergone COVID-19 were included in group I, and 34 patients with coronary artery disease / CHF without COVID-19 in the anamnesis were included in group II studied. The assessment of the clinical and functional state of CHF was carried out using the six-minute walk test (SMWT) and according to the scale for assessing the clinical state (SACS). The level of fibromarker Gal-3 in blood serum was assessed by the method of enzyme-linked immunosorbent assay (ELISA) ELISA. Results. The results obtained during the study indicate the unfavorable effect of an increased level of the biomarker of fibrosis Galectin-3 on the clinical and functional state and hemodynamic parameters of patients with coronary artery disease complicated by CHF against the background of the transferred COVID-19, this adverse effect of which persists in the postcovid period. Also, a key mediator of fibrotic and proliferative processes, Galectin-3, can serve as a predictor not only for postcovid complications, but also for the development and progression of CHF with preserved systolic function due to coronary artery disease. Conclusion. Thus, Galectin-3, a key mediator of fibrotic and proliferative processes, can serve as a specific biomarker for early diagnosis of the development of severe CHF and cardiovascular complications in CHD patients who have undergone COVID-19 in the post-covid period.

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