Rhabdomyosarcoma (RMS) is a rare type of malignant tumor originating from striated muscles. The majority (approximately 75%) are embryonic rhabdomyosarcoma (ERMS) and alveolar rhabdomyosarcomas. The distinction between ERMS and ARMS is of great clinical importance, since the latter gives the worst prognosis. Aims. This study has been done to assess the histopathological and IHC features of rhabdomyosarcoma in patients of the Uzbek population in correlation with age, sex, primary localization and subtype of the tumor. Materials and methods. The study has been done over a period of five years from 2017 to 2021 in the bases of LLC “Ipsum pathology”, first public private project in Uzbekistan realized with Tashkent City Oncology center. Thirty-six cases of proven rhabdomyosarcoma were selected from the archive of the department for the retrospective analysis. Intensity of immunohistochemical reactions with antigens Vimentin, MyoD1, Myogenin, SMA, Desmin, ki-67, PanCK, S100, MDM2, INI I, CD20, CD45, CD3, CD68, CD34, ERG, CD31, SALL4, CDK4, Caldesmon, CD138, CD99, Synaptophisin, WT1, TLE1, EMA, TdT, HMB45, p63 were assessed qualitatively (presence / absence of reaction). Immunohistochemistry was performed on Roche antigens, on an automated Ventana XT system, USA. Results. The study reveals that RMS among adults and children/adolescents made up 0.06%. Incidence of RMS among pediatric and adult age groups does not reveal a big difference, 53 and 47 % relatively. Sex distribution privileged to males with 61%, whereas females made up 49%. The most frequent primary site of locations were head and neck (28%) and genitourinary tract (22%). It was interesting to found that histological subtype of RMS, NOS was the mostly reported – 22%, whereas embryonal – 21% and alveolar – 20%.
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Botiralieva, G.K.; Polatova, D.Sh.; Konovalov, D.M.; and Sharma, Sh.
"CLINICOPATHOLOGIC FEATURES OF RHABDOMYOSARCOMA AND IMMUNOHISTOCHEMICAL PROFILING IN UZBEK POPULATION,"
Central Asian Journal of Medicine: Vol. 2021
, Article 15.
Available at: https://uzjournals.edu.uz/tma/vol2021/iss3/15