Central Asian Journal of Medicine


The aim of our work was to analyze the association of polymorphic loci rs1042713 (Arg16Gly) and rs1042714 (Gln27Glu) of the β2-adrenoreceptor (ADRB2) gene in children of the Uzbek population with recurrent bronchial obstruction(RBO). The material for the study was patients with RBO of Uzbek ethnicity aged from 1 to 15 years. The comparison group included children with acute obstructive bronchitis(OOB), bronchial asthma (BA), and practically healthy children of the same age and population. In the molecular genetic study, a diagnostic kit was used to detect polymorphisms in human genes by polymerase chain reaction. In the molecular genetic study, a diagnostic kit was used to detect polymorphisms in human genes by polymerase chain reaction. The results of the obtained studies showed that children who possess polymorphic variants of Gln27Glu of the ADRB2 gene of the G/G mutational genotype are predisposed to the development of recurrent bronchial obstruction in children. Analysis of the prevalence of Gln27Glu polymorphic variants of the ADRB2 gene in patients with RBO showed that the owners of the G/G mutational genotype have a high risk of predisposition to the development of the disease.

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