Purpose of the study. To study the features of the frequency distribution of alleles and genotypes of IL-1β (rs1143627) gene polymorphism, its role in the development of ITP in people of the Uzbek ethnic group. Material and methods: The study included 89 patients with ITP (median age - 41 ± 1.7 years) (main group) who were admitted for examination by the RSPMCH in the period from 2012 to 2018. Detection of IL-1β (rs1143627) polymorphism was carried out by SNP-PCR. Results and its discussion. Carriage of the IL-1β gene polymorphism (rs1143627) is not associated with the risk of developing immune thrombocytopenia.
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Karimov, Hamid Y.; Matkarimova, Dilfuza S.; and Boboev, Kodirjon T.
"ALLELIC POLYMORPHISM OF THE IL-1β (rs1143627) GENE IN PATIENTS WITH IMMUNE THROMBOCYTOPENIA,"
Central Asian Journal of Medicine: Vol. 2021
, Article 4.
Available at: https://uzjournals.edu.uz/tma/vol2021/iss1/4