Central Asian Journal of Medicine


Purpose of the study. To study the features of the frequency distribution of alleles and genotypes of IL-1β (rs1143627) gene polymorphism, its role in the development of ITP in people of the Uzbek ethnic group. Material and methods: The study included 89 patients with ITP (median age - 41 ± 1.7 years) (main group) who were admitted for examination by the RSPMCH in the period from 2012 to 2018. Detection of IL-1β (rs1143627) polymorphism was carried out by SNP-PCR. Results and its discussion. Carriage of the IL-1β gene polymorphism (rs1143627) is not associated with the risk of developing immune thrombocytopenia.

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1. Zotova I.I. Klinicheskie i molekularno-geneticheskie pokazateli tyajesti techeniya I effektivnosti terapii u bolnih immunnoy trombocitopeniey. Avtoref. dis. S-Peterburg, 2018. S. 22. 2. Zotova I.I. Osobennosti allelnogo polimorfizma genov nekotorix citokinov u bolnix hronicheskoy immunnoy trombocitopeniey/ I.I. Zotova, S.I. Kapustin, Yu.S. Drijun, S.P. Svitina, A.A. Pavlova, S.S. Bessmeltsev, A.V. Chechetkin, S.V. Gritsaev // Vestnik gematologii. – 2017. – Т. 13, №3. – S.31. 3. Ezzat D. A., Hammam A. A., El Malah W. M., Hussein S. A. DNA methyltransferase 3B gene promotor and interleukin-1 receptor antagonist polymorphisms in Egyptian children with immune thrombocytopenic purpura. Egiptian jornal of Haemotology. 2016 | Volume : 41 | Issue : 3 | Page : 121-127.; 4. Fatma E.S., Ahmed K.S., Nihal E.K.S., Salwa H.Y. Cytokines and immunoglobulin derangement in egyptian children with primary immune thrombocytopenic purpura. Egypt J Haematol [serial online] 2018 [cited 2019 Oct 20]; 43:1-4. Available from: http://www.ehj.eg.net/text.asp?2018/43/1/1/238541; 5. Kim J. IL-1B-31 and IL-1Ra polymorphisms associated with increased host susceptibility to immune thrombocytopenia/ Blood Res 2017;52:264-9. https://doi.org/10.5045/br.2017. 52. 4.235. 6. Kuhne T., Berchtold W., Michaels L.A., Wu R., Donato H., Espina B., Tamary H., Rodeghiero F., Chitlur M., Rischewski J. et al. Newly diagnosed immune thrombocytopenia in children and adults: a comparative prospective observational registry of the Intercontinental Cooperative Immune Thrombocytopenia Study Group. Haematologica. 2011; 96(12):1831–7. 7. Li H., Zhou Z., Tai W., Feng W., Zhang D., Gu X. et al. Decreased frequency of IL-17F rs763780 site allele G is associated with genetic susceptibility to immune thrombocytopenia in a Chinese population. Clin Appl Thromb Hemost 2017 Jul 30; 23(5):466-471. 8. Lingjia Y, Chunmei Z, Liping Z, Yongyu S, Xuebin J. Biomarkers for immune thrombocytopenia. Biomark Res. 2015; 3:19. 9. Vilela, Josie Fadul. Investigation of interleukin-1 (IL-1), IL1RN, IL-4, IL-6 and IL-10 gene polymorphism adult patients with immune thrombocytopenic purpura. 2012. 146 p. ]. 10. Yadav D. K., Tripathi A. K., Gupta D., Shukla S., Singh A. K., Kumar A., Agarwal J., Prasad K. N. Interleukin-1B (IL-1B-31 and IL-1B-511) and interleukin-1 receptor antagonist (IL-1Ra) gene polymorphisms in primary immune thrombocytopenia. Blood Res. 2017 Dec; 52(4):264-269. English. https://doi.org/10.5045/br.2017.52.4.264.



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