•  
  •  
 

Central Asian Journal of Medicine

Abstract

The article clarifies role of the monooxygenase system in the development of acute pancreatitis. Authors determine cytochrome P-450 possesses unique properties that ensure the maintenance of chemical homeostasis in physiological and pathological states of the internal organism medium. The liver is the main organ supporting physico-chemical homeostasis, detoxification of endogenously formed and exogenously introduced xenobiotics into the body. But there is also extrahepatic metabolism of foreign compounds. The intestine plays an important role in this process. Endogenous intoxication syndrome disrupts metabolism and reduces the functional activity of natural detoxification systems, in particular by inhibiting the liver’s monooxygenated detoxification system.

First Page

108

Last Page

115

References

1. Ashurova O.Yu. Aktivnost' monooksigenaznoy i nitrergicheskoy sistem v mikrosomakh pecheni pri deystvii na organizm induktorov i ingibitorov lekarstvennogo metabolizma// Nauka i innovatsii – sovremennyye kontseptsii. Sb. nauch. statey po itogam raboty Mezhdunar. Nauch. foruma. M., 2020. - S. 60-64. 2. Myshkin V.A., Yenikeyev D.A. // Trudy V Vseross. Nauchn.-prakt. konf. s mejdunar. uchastiyem «Voprosy patogeneza tipovykh patologicheskikh protsessov». Novosibirsk, 4-5 aprelya 2013. – S. 81-84. 3. Meloshkin A.V. Patogeneticheskiye osnovy sovershenstvovaniya lechebnykh programm detoksikatsionnoy terapii pri ostrom peritonite: diss. kand. med. nauk – Saransk: 2017 – 6s. 4. Petrosyan E.A., Sergiyenko V.I., Rykunova V.Ye. Biotransformatsiya kseno- i endobiotikov pri peritonite. Eksper. i klin. gastroenterologiya. 2017;(2):92-96. 5. Rakitskiy V.N., Yudina T.V. Antioksidantnyy i mikroelementnyy status organizma: sovremennyye problemy diagnostiki // Vestn. RAMN. 2005.-№3.- S.33-36; 6. Sivkov A.S., Paukov S.V., Ruvinov YU.V., Kukes I.V. Individual'naya bezopasnost' farmakoterapii pri otsenke aktivnosti izofermenta tsitokhroma R-450 3A4 (SUR3A4) // Klin.med. – 2010. - №2. – S. 61 – 67. 7. Yablokov Ye.O., Gnedenko O.V. Mol'nar A.A Ivanov A.S. Usanov S.A. Archakov A.I. Molekulyarnoye uznavaniye mezhdu belkami v P-450-zavisimykh monooksigenaznykh sistemakh» //Mater. IV s"yezda biofizikov Rossii, 20-26 avgusta 2012, N/Novgorod, Rossiya, 2012 S.325. 8. Yablokov Ye.O. Molekulyarnoye uznavaniye, affinnost' i termodinamika belok-belkovykh vzaimodeystviy v tsitokhrom p450- zavisimykh monooksigenaznykh sistemakh: diss. kan. med. nauk: M.: 2014 -30 s. 9. Altuve A., Silchenko S., Lee K.H., Kuczera K, Terzyan S., Zhang X, Benson D.R., and Rivera M., Probing the differences between rat liver outer mitochondrial membrane cytochrome b5 and microsomal cytochromes b5. //Biochemistry 40 (2001) 9469-83. 10. Perret A., and Pompon D., Electron shuttle between membrane-bound cytochrome P450 3A4 and b5 rules uncoupling mechanisms // Biochemistry 37 (1998) 11412-24. 11. Bashir Q, Scanu S, Ubbink M. FEBS J. 2011; 278:1391–1400. [PubMed: 21352493] 12. Correia MA, Mannering GJ. DPNH synergism of TPNHdependent mixed function oxidase reactions // Drug Metab Dispos 1973;1:139–149. 13. Enoch HG, Strittmatter P// J. Biol. Chem. 1979; 254:8976–8981. [PubMed: 113406] 14. Ingelman-Sundberg M. (2005) Toxicol. Appl. Pharmacol., 207. P. 52-56 15. Iyanagi T, Mason H.S. //Biochemistry. 1973; 12:2297–2308. [PubMed: 4145653] 16. Oshino N., Imai Y., Sato R. A function of cytochrome b5 in fatty acid desaturation by rat liver microsomes // J. Biochem (Tokyo) 1971;69:155–167 17. Hall P., Gustafsson I.A. (Ed.) // Biochemistry, Biophysics and Regulation of Cytochrome P-450, Elsevier/North-Holland Biomed Press, Amsterdam. 1980 – P. 461-477 18. Roman L.J., Masters B.S. Textbook of Biochemistry with Clinical Correlations. Devlin, TM., editor; Mowat CG, Gazur B, Campbell LP, Chapman SK // Arch. Biochem. Biophys. 2010; 493:37–52. 19. Structural–functional organization of cytochrome P-450 containing monooxygenase and some aspects of modeling Author links open overlay panel M.S.Gordeziani, T.G.Varazi, M.V.Pruidze Durmishidze Institute of Biochemistry and Biotechnology of Agricultural University of Georgia, 240, David Agmashenebeli Alley, Tbilisi, 0159, Georgia 20. Yu Y., Yamasaki H., Kita K., and Takamiya S., Purification and molecular characterization of a novel b5-type cytochrome of the parasitic nematode, Ascaris suum //Arch Biochem Biophys 1996. - №328- P. 165-72

Share

COinS
 
 

To view the content in your browser, please download Adobe Reader or, alternately,
you may Download the file to your hard drive.

NOTE: The latest versions of Adobe Reader do not support viewing PDF files within Firefox on Mac OS and if you are using a modern (Intel) Mac, there is no official plugin for viewing PDF files within the browser window.