•  
  •  
 

Central Asian Journal of Medicine

Abstract

Objective: to study the features of the immune and neuroendocrine links of the reproductive function disorder pathogenesis in women with autoimmune thyroiditis and on this basis to substantiate fertility reproduction. Material and Methods: The research presents the analysis of the dynamic monitoring results and the evidences of clinical, immunologic and hormonal examinations of 325 women with reproductive disorders and autoimmune thyroiditis. The control group included 30 healthy women of maternal age. Results and conclusions: clarified and expanded conceptions on the immunological and neuroendocrine links of the reproductive disorders formation pathogenesis in women with AI``T; presented data of immunoregulatory and effector role cytokines in the progression of immune system dysregulation in various clinical events of AIT in women with reproductive failure; the relationship between immune and endocrine changes was investigated for the first time and progression of reproductive disorders was shown in association with a number of unidirectional changes in the immune system: imbalance of cytokines, a decrease in the number of activation markers of early activation lymphocytes, increase of late activation lymphocytes, increase in the number of the B-lymphocytes quantity, antibodies to thyroperoxidase and antibodies to thyroglobulin; it is established that the pathogenesis of menstrual cycle and reproductive disorders in women with AIT is caused by a combination of endocrine changes and immunological abnormalities, the nature and severity of immunological and endocrine disorders depends on the stage of AIT progress; the features of the formation of ovarian insufficiency syndrome in patients with AIT were studied taking into account the stage of development of the autoimmune process.

First Page

65

Last Page

91

References

1. Alieva S. A., Odamanova M. A., Allakhkulieva S. Z., Khashayeva T. H. the Value of antiphospholipid antibody circulation in women with autoimmune thyroid diseases and fetal loss syndrome in anamnesis // Obstetrics, gynecology and reproduction. - 2015. - Vol. 9. - No. 1. - P. 13-18. 2. Andreeva A.V., Suchkova E. N., Gadzhieva S. I. Population of antithyroid autoantibodies as a source of antibodies of various levels of specificity and functionality: clinical significance of the phenomenon of combinatorics in monitoring patients with autoimmune diseases of the thyroid gland / / Clinical and experimental thyroidology. - 2011. - Vol. 7, No. 2. - P. 19-27. 3. Asatova M. M., Muhiddinova U. T. Study of the effectiveness of various treatment protocols for patients with hypogonadotropic ovarian insufficiency // Bulletin of the General practitioner. - 2010. - no. 4. - P. 4-7. 4. Asatova M. M., Nasirova G. U. Dynamics of hormonal parameters in pregnant women with initial ovarian hyperandrogenism // News of dermatology and venereology and reproductive health. - 2011. - №3. - P. 9-12. 5. Akhmedova sh. U., Sharipova F. K. Influence of congenital transient hypothyroidism on the neuropsychological development of children of the first three years: scientific publication / / Journal of theoretical and clinical medicine. - 2012. - №6. - P. 9-12. 6. Basic and clinical endocrinology / David Gardner, Dolores Shobek / TRANS. from English. edited by G. A. Melnichenko. - Moscow: Binom, 2011. - 695 p. 7. Balabolkin M. I., Klebanova E. M., Kreminskaya V. M. Fundamental and clinical thyroidology (manual). Moscow: Meditsina, 2007, 816 p. 8. Belousova S. V., Manchuk V. T., Savchenko A. A., Kadricheva S. G. Parameters of the immune status in women with autoimmune thyroiditis with various states of thyroid function / / Medical immunology. - 2007. - T9. - №2-3. - P. 192-193. 9. Vasiliadi G. K. Problematic issues of autoimmune thyroiditis. Bulletin of new medical technologies-2012-vol. XIX, no. 3-P. 137-139. 10. Vedishchev S. I., Prokopov A. Yu., Zhabina U. V., Osmanov E. M. Modern ideas about the causes of miscarriage // Vestnik TSU. - 2013. - Volume 18. - No. 4. - P. 1309-1312. 11. Gataulina R. G. Functional state of the thyroid gland in patients with tumors and ovarian tumours, suffering from infertility // Vestn. of a.... and gin. - 2001. - P. 38-40. 12. Dambaeva I. M., Sanzheeva D. N., Sharapova T. D. Indicators of the immune status of patients with autoimmune diseases of the thyroid gland / / Bulletin of the East Siberian scientific center SB RAMS. - 2007. - № 5. - Pp. 102-103. 13. Dubkova E. A., Marinkin I. O., Sokolova T. M., Usova A.V. Correlation of thyroid pathology and polycystic ovary syndrome in women with infertility // Medicine and education in Siberia, 2013, no. 4, Pp. 62-67. 14. Ioffe I. V., Khrabrova E. P., Lyashenko E. A. Investigation of serum immunoregulatory cytokines concentration in autoimmune thyropathies // Ukrainian journal of clinical and laboratory medicine. - 2013. - Volume 8. - No. 2. - P. 143-146. 15. Isaeva M. A., Bogatyreva Z. I. Autoantibodies of various levels of specificity and functionality in the pathogenesis and diagnosis of autoimmune diseases of the thyroid gland. // Clinical and experimental thyroidology. - 2007. - Vol. 3, No. 4. - P. 27-34. 16. Ismailov S. I., Abdurazakova D. S. Frequency of occurrence of elevated concentrations of antibodies to thyroid peroxidase in women living in the Andijan region // Journal of theoretical and clinical medicine. - 2014. - №6. - P. 9-12. 17. Kesaeva E. S., Basieva O. O. Screening of thyroid pathology and cytokine status in young people. / Bulletin of new medical technologies-2012-Vol. 19, No. 2-Pp. 46-48. 18. Kozlov V. A., Yarilin A. A., Ametov A. S., Nikonova M. F., Burmenskaya O. V., Trofimov D. Yu. Natural regulatory T-cells and associated cytokines in chronic autoimmune thyroiditis. / Immunopathology and clinical immunology. - 2008. - №6. - P. 357-361. 19. Kravets E. B., Urazova O. I., Nedosekova Yu. V., rogaleva A.V. About apoptosis of lymphocytes in autoimmune thyropathies // Problems of endocrinology, 2010, Vol. 56, No. 3, Pp. 16-20. 20. Lanin D. V., Zaitseva N. V., Dolgikh O. V. Neuroendocrine mechanisms of regulation of immune system functions // Advances in modern biology, 2011, Vol. 131, No. 2, Pp. 122-134. 21. Maklakova T. P., Zorina V. N., Shepel T. T., Boyko O. N., Zorina R. M., Zorin N. A. the Content of immunoregulatory proteins and cytokines in the blood in autoimmune diseases of the thyroid gland // Problems of endorinology, 2014, no. 6, Pp. 10-13. 22. Melnikov V. L., Mitrofanova N. N., Melnikov L. V. Autoimmune diseases / Textbook, Penza. - 2015. - 69c. 23. Guidelines of the European thyroid Association for the management of patients with subclinical hypothyroidism during pregnancy and childhood / / Eur. Thyroid J.-2014. - No. 3. - P. 76-94. 24. Nazhmutdinova D. K., Nasyrova sh. sh., Adhamova N. P. Interrelation of functional States of the thyroid gland and the reproductive system in women with iodine deficiency // Problems of reproduction, 2012, no. 4, Pp. 31-34. 25. Pavlova T., Malyutina 33. Chaika V. K., Demina T. N., alipova N. F. the Role of autoimmune thyroiditis in the Genesis of miscarriage // Neonatology, surgery and perinatal medicine. - 2011. - T1. - №2. - P. 91-94. 34. Yunusov A. A. State of the cytokine system in autoimmune thyroiditis in women of reproductive age // Bulletin of KRSU, 2014, Vol. 14, No. 4, Pp. 168-170. 35. Yukhnovets A. A. Diagnostics and treatment of autoimmune thyroiditis. // Vestnik of Vitebsk State Medical University, 2004. – Vol. 3. - No. 3. – S. 47-53. 36. Abalovich M., Mitelberg L., Allami S. and others. Subclinical hypothyroidism and autoimmunity of the thyroid gland in women with infertility. Gynaecol Endocrinol, 2007, No. 23, Pp. 279-283. 37. Sharp y. Hyperthyroidism in patients older than 55 years: analysis of etiology and management / / gerontology. - 2003-Vol. 49(5). - Pp. 316-323. 38. Dosiu K, Sanders GD, Araki SS, Crapo LM. Screening of pregnant women for autoimmune thyroid diseases: cost-effectiveness analysis. Eur J Endocrinol. - 2008. - №158. - P. 841-851. 39. Duntas LH. Environmental factors and autoimmune thyroiditis. Nat Clin Practice Endocrinol Metab 2008. - No. 4. - Pp. 454-460. 40. Effraimidis G., Strieder T. G., Tijssen J. G., Wiersinga W. M. The natural history of the transition from euthyroidism to apparent autoimmune Hypo-or hyperthyroidism: a prospective study / / Eur. J. Endocrine. 2011. - no. 164. - Pp. 107-113. 41. Fang, Y. interleukin-10 contributes to the resolution of granulomatous experimental autoimmune thyroiditis / Y. Fang, G. C. Sharp, H. Braley-Mullen / / Am. journal of Pathology j. - 2008. - Vol. 172. - N 6. - P. 1591-1602. 42. Ganesh B. B., Bhattacharya P., Gopisetti A., Prabhakar B. S. the role of cytokines in the pathogenesis and suppression of autoimmunity of the thyroid gland / / J Interferon Cytokine Res. - 2011. – №31(10). - Pp. 721-731. 43. Jones RL Hannan NJ, Kaitu u TJ, et al. Determination of chemokines that are important for recruiting white blood cells to the human endometrium during embryo implantation and menstruation. J Clin Endocrinol Metab. - 2004. - Volume 89. - Pp. 6155-6167. 44. Kari S., Flynn J. S., Zulfikar M., Snower D. P., Elliot B. E., Kong Y. S. enhanced autoimmunity associated with the induction of tumor immunity in mice susceptible to thyroiditis / / thyroid gland. – 2013. – 23(12). – P. 1590-1599. 45. Klecha A. J., Barreiro Arcos M. L., Frick L., Genaro a.m., Kremashi G. immuno-endocrine interactions in autoimmune diseases of the thyroid gland. Neuroimmunomodulation. – 2008. – №15(1). - Pp. 68-75. 46. McLachlan, S. M. violation of tolerance to thyroid antigens: changing concepts of autoimmunity of the thyroid gland / S. M. McLachlan, B. Rapoport / / Endocr. Rev.-2014. - Vol. 35. - Pp. 59-105. 47. Polyzos NP, Sakkas E, Vaiarelli A, etc. Thyroid autoimmunity, hypothyroidism, and ovarian reserve: a cross-sectional study of 5,000 women based on age-related AMH values. Hum Reprod. 2015 – - 16P. 48. Saranak L., Zivanovich S., Belakovich B., Stamenkovich H., Novak M., Kamenov B. Why is the thyroid gland so susceptible to autoimmune diseases? // Horm Res Paediatr. - 2011. - Volume 75(3). - Pp. 157-165.

Share

COinS
 
 

To view the content in your browser, please download Adobe Reader or, alternately,
you may Download the file to your hard drive.

NOTE: The latest versions of Adobe Reader do not support viewing PDF files within Firefox on Mac OS and if you are using a modern (Intel) Mac, there is no official plugin for viewing PDF files within the browser window.