Background. Progressive development and significant advances in the field of cellular biology and technologies, developmental physiology and gene engineering resulted in the formation of a new era and branch of medicine — regenerative medicine. This new branch includes science-based and safe approaches for creating new cells and tissues and restoring the structure and functions of damaged ones. The objective of the regenerative medicine is to replace or regenerate human cells, tissues, or organs. Such a replacement helps to recover the normal function that has been lost. An important change in the paradigm of regenerative medicine is the switching to a cellular therapy. In this investigation, the authors studied two surgical methods for the treatment of vitiligo and conducted a comparative analysis of post-treatment repigmentation. Research objective: to conduct a comparative analysis of cell transplantation methods in the treatment of vitiligo. Materials and methods. In this research patients with vitiligo underwent a surgical treatment. Depigmented patches were studied according to the localization of the pathological focus. The transplantation of non-cultured epidermal cells was performed in 63 patients. The transplantation of a mixture of hair follicle cell suspension (NCECS+NCORSHFS) obtained from the scalp of a patient with vitiligo in combination with the mixture of non-cultured epidermal cell suspension (NCECS) was performed in 50 patients. Before transplantation, the prepared suspension was injected into the depigmented patch by mesotherapy. Besides, the authors conducted a comparative evaluation of repigmentation indicators and treatment efficacy. Findings. The performed method of surgical treatment for vitiligo is highly effective, confirmed by the absence of depigmentation signs immediately on the treatment completion. The recommended treatment course is 1-3 procedures, depending on the location and scope of the pathological process. The use of this method will contribute to efficacy improvement of vitiligo treatment.
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Sabirov, U. Yu.; Azimova, F. V.; and Toirov, B. A.
"TRANSPLANTATION OF NON-CULTURED AUTOMELANOCYTES IN COMBINATION WITH HAIR FOLLICULE SUSPENSION IN THE TREATMENT OF VITILIGO,"
Central Asian Journal of Medicine: Vol. 2020
, Article 4.
Available at: https://uzjournals.edu.uz/tma/vol2020/iss3/4