Central Asian Journal of Medicine


In this paper, was analyzed the data of scientific research on the importance of extragenital diseases in the structure of maternal mortality. In the civilized world’s countries, extragenital diseases occupy the first place among the causes of maternal mortality. According to the WHO and many scientists, among the deceased women in childbirth and puerperas, 37.9% died of extragenital pathology, of which 35.3% were respiratory diseases, 14.1% - diseases of the circulatory system, 7.0% - injuries and poisoning, 3, 5% - neoplasms, 2.4% each - some infectious diseases, congenital anomalies; 1.2% each - diseases of the nervous system, digestive organs, musculoskeletal system. Of extragenital pathologies, chronic conditions etiologically unrelated to pregnancy are often found, such as cardiovascular diseases; systemic diseases of the connective tissue; bronchopulmonary diseases; digestive tract diseases; liver disease kidney disease chronic diseases of the blood system; diseases of the nervous system; diabetes and others.

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1. Cohen H, Rossignol M. [Maternal death by stroke. Results from the French enquiry into maternal deaths, 2010-2012]. Gynecol Obstet Fertil Senol. 2017 Dec;45(12S):S65-S70. doi: 10.1016/j.gofs.2017.10.017. Epub 2017 Nov 15. 2. Ducas RA, Elliot JE, Melnik SF, et al. Cardiac Problems in Pregnancy. Cardiovascular magnetic resonance in pregnancy: insights from the cardiac hemodynamic imaging and remodeling in pregnancy (CHIRP) study. Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance. 2014 Jan 3;16:1. doi: 10.1186/1532-429X-16-1. 3. Eguchi E, Iso H, Wada Y, Kikuchi S, Watanabe Y, Tamakoshi A; Japan Collaborative Cohort Study Group. Parental history and lifestyle behaviors in relation to mortality from stroke among Japanese men and women: the Japan Collaborative Cohort Study. J Epidemiol. 2012;22(4):331-9. 4. Foo L, Bewley S, Rudd A. Maternal death from stroke: a thirty year national retrospective review. Eur J Obstet Gynecol Reprod Biol. 2013 Dec;171(2):266-70.doi: 10.1016/j.ejogrb.2013.09.021. 5. França EB, Passos VMA, et al. Cause-specific mortality for 249 causes in Brazil and states during 1990-2015: a systematic analysis for the global burden of disease study 2015. Popul Health Metr. 2017 Nov 22;15(1):39.doi: 10.1186/s12963-017-0156-y. 6. Ghali MAE, Kaabia O, Mefteh ZB, Jgham M, Tej A, Sghayer A, Gouidar A, Brahim A, Ghrissi R, Letaief R. Acute appendicitis complicating pregnancy: a 33 case series, diagnosis and management, features, maternal and neonatal outcomes. Pan Afr Med J. 2018 Jul 16;30:212. doi: 10.11604/pamj.2018.30.212.14515. 7. Pakarinen P. et al. Iron Deficiency Anemia: Recommended Guidelines for the Prevention, Detection, and Management Among U.S. Children and Women of Childbearing Age. 2001. 8. Ponka P., Beaumont C., Richardson D.R, 1998. Function and regulation of transferrin and ferritin. Semin Hematol. 1998 Jan;35(1):35-54. 9. Ponka P., Beaumont C., Richardson D.R. Molecular basis of inherited microcytic anemia due to defects in iron acquisition or heme synthesis. Haematologica. 2009 Mar; 94(3): 395–408. 10. Shani H, Kuperstein R, Berlin A, Arad M, Goldenberg I, Simchen MJ. Peripartum cardiomyopathy – risk factors, characteristics and long-term follow-up. J Perinat Med. 2015 Jan;43(1):95-101. doi: 10.1515/jpm-2014-0086. 11. Theilen LH, Fraser A, Hollingshaus MS, Schliep KC, Varner MW, Smith KR, Esplin MS. All-Cause and Cause-Specific Mortality After Hypertensive Disease of Pregnancy. Obstet Gynecol. 2016 Aug; 128 (2): 238-44. doi: 10. 1097 /AOG. 0000000000001534. 12. Tranquilli AL, Landi B, Giannubilo SR, Sibai BM. Preeclampsia: No longer solely a pregnancy disease. Pregnancy Hypertens. 2012 Oct;2(4):350-7. doi:10.1016/j.preghy.2012.05.006. 13. Umesawa M, Kobashi G. Epidemiology of hypertensive disorders in pregnancy: prevalence, risk factors, predictors and prognosis. Hypertens Res. 2017 Mar;40(3):213-220. doi: 10.1038/hr.2016.126. 14. Abdullahodjaeva M.S., Allanazarov I.M., Babanov B.Kh. Analysis of the causes of maternal mortality according to the Republican Pathological Center // National Model for Maternal and Child Health in Uzbekistan: “Healthy Mother - Healthy Child”: abstracts / International Symposium.-Т .: IPTD Uzbekistan, 2011. - 160 p. - Tashkent, 2011 .-- P. 9-10. 15. Abdullahodjaeva M.S., Allanazarov I.M., Babanov B.Kh. Extragenital diseases as the main cause of maternal mortality // Pediatrics (Uzbek). - 2003. Special. issue - P. 101–103. 16. Asadov D.A., Vafokulova U. B. Organizational, medical and social aspects of reducing maternal mortality in the high fertility region: Abstract of MD dissertation.-Tashkent, 1993.-35p. 17. Bobojonov A.S. Death and its epidemiological Properties in women of childbearing age // Uzbekistan Journal of Medicine.-2003.-№ 3.-3–8 p. 18. Dvotetskiy L.I., Zaspa E.A., Litvitsky P.F. et al. Free-radical processes in patients with iron deficiency anemia during treatment with iron preparations // Ter. arch. - 2006; 78 (1): 52–57. 19. Dvotetskiy L.I., Zaspa E.A., Litvitsky P.F., et al. Key issues of iron deficiency anemia. The pathogenesis and therapy of iron deficiency anemia in pregnant women. 2006. "Therapeutic Archive" medical journal. Page 8-12. 20. Egorova A.T., Baranyuk N.V. , Maiseenko D.A. Cases of maternal mortality in diseases of the pancreatobiliary system. Breast cancer "Medical Review" No. 24 dated 04.11.2014 p. 1760. 21. К. Kamilov A.I. Protection of motherhood and childhood in the Republic of Uzbekistan: state and prospects // Medical Journal Uzbekistan .- 2011 - No. 6.- P. 18–21. 22. Kenjaeva G.R., Polikarpova N.V., Babadjanov A.S. Maternal mortality - an expert analysis and assessment of the significance of the liver in thanatogenesis // Physician Bulletin.-Tashkent, 2009.-No. 3.-P.173-174. 23. Mamatkulov B.M., Ustamadalieva D.A., Khakimova D.S. The main causes and risk factors for maternal mortality in Ferghana Valley. The scientific journal "Young Scientist". -Kazan. 07.2015. Part III. Page 302-304. 24. Medved I.V. The main issues of extragenital pathology. Medical Aspects of Healthy Health. 6 (46) 2011.P. 5-11. 25. Milovanov A.P., Dobryakov A.V. The increasing importance of extragenital pathology in the structure of maternal mortality in Russia. Moscow. Pathology Archive. 02. 2018. Page 3-6. 26. Polikarpova N.V. Outcomes of childbirth in women with pathology of the hepatobiliary system // Young Scientist. - 2017. - No. 18. - P. 125-126. - URL https://moluch.ru/archive/152/43218/. 27. Radzinsky V.E., Smalko P.Ya. Obstetrics: A Guide. 2001. Biochemistry of placental insufficiency. - M.: Publishing House of RUDN, 2001. - P. 275. 28. Sidorova I. S, Protopopova T. A., Repin A. B. et al. // Materials of the III Russian Forum “Mother and Child”. - M., 2001. - S. 196–197



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