Central Asian Journal of Medicine


Background. Morphofunctional state of newborn immunity organs, in particular lymph nodes, during sepsis has not been well-studied so far. This research was dedicated to study the morphological and morphometric features of the lymph nodes of infants who died in the neonatal period because of sepsis. Methodology. The research materials were samples of paratracheal and mesenteric lymph nodes which were taken from 42 neonatal infants’ autopsy specimens. Morphological, histochemical and morphometric methods were used to study lymph node samples obtained from different localizations. Morphometric analysis was applied to evaluate the lymph node diameter, cortex (B-zone) width, paracortical T-zone as well as the medullary layer and also to determine the paracortical zone/cortex and cortex/medullary layer ratio or the coefficient. Results. The neonatal sepsis in the newborns is accompanied by intrauterine-acquired and secondary immunodeficiencies. It was revealed that in intrauterine-acquired immunodeficiency, the main morphological and functional zones of the peripheral organs of immunogenesis are shown to be immature and hypoplastic due to underpopulation of lymphocytes. Depending on the disruption level of the humoral or cell-mediated immune system, lack of lymphocyte activation in light reproduction centers as well as corresponding structural and functional zones depletion of lymph nodes occur in secondary immunodeficiencies. They are followed by zone replacement with reticular and connective tissue. Conclusions. In intrauterine sepsis, there was the lag in the main morphologic formation which is functional zones of the lymph nodes, in postnatal sepsis on the background of the secondary immunodeficiency that the devastation of the corresponding structural and functional zones of the lymph nodes was observed according to the damage of the cellular or humoral immunity.

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