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Central Asian Journal of Medicine

Abstract

Introduction. Extramural pneumonia - is one of the most common infectious and inflammatory diseases in the world. The main etiological cause of extramural pneumonia in both children and adults is the bacteria Streptococcus pneumoniae. Staphylococcal pneumonia is observed in patients older than 60 years, contributes to the exacerbation of chronic diseases, often becomes the causative agent of nosocomial pneumonia. Klebsiella pneumoniae is considered the most common cause of severe nosocomial pneumonia, causing the disease in most cases in patients suffering from alcoholism, diabetes and immunodeficiencies. Objective. To study of functional morphology of lung tissue cells in experimental pneumonia. Material and methods. Used white outbred rats of the Wistar line. Experimental inflammation was caused by introducing into the tracheal cavity a bacterial suspension containing cultures of virulent strains of pneumococcus, Staphylococcus and Klebsiella against the background of cold factor. General morphological and electron microscopic studies of lung tissue were carried out on 5, 10, 15, 21, 30, 60 and 90 days of the experiment. Research result. The effect of virulent cultures of staphylococcus, streptococcus and Klebsiella against the background of hypothermia causes the formation of an active inflammatory process in the lungs with subsequent transition to a subacute and protracted form. In our case, the transition of the acute stage (5-10 days) to subacute (or prolonged) fluctuated between 15 and 21 days of the experiment. The following lines were dominated by atrophic and sclerotic changes in lung tissue. Violations of the epithelial stromal relationships in the lung tissue cause destructive, atrophic and sclerotic processes. Conclusion. Under the influence of virulent strains of pneumotropic bacteria in the lung tissue, the processes of inflammation, destruction with extensive destruction of both the epithelial cover and the interstitium, as well as the processes of pneumosclerosis prevail. Disproportion between epithelial and immunocompetent cells leads to a decrease in the functional state of alveolar epithelial cells.

First Page

125

Last Page

152

References

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