Central Asian Journal of Medicine


Introduction. Children living in ecologically unfavorable regions often have a risk to acute bronchopulmonary diseases with their own peculiar course. These children have frequent relapses and a complicated course of pulmonary and respiratory diseases. So the present research covers data and analysis of homeostatic system and interleukins level in early age children with acute acquired pneumonia and acute bronchitis, as well as influence of ecological environment on the disease development. The aim of the research is to evaluate the features of the clinical course and hemostasis system in children with acute bronchopulmonary diseases with different environmental living conditions. Materials and methods. The research involved 42 children with acute acquired pneumonia and 34 children with acute bronchitis (1st group) living in the Aral Sea region (within the territory of Khorezm region) and 40 children with acute acquired pneumonia and 30 children with acute bronchitis aged 1 to 3 years living in the Samarkand region (2nd group). Results and discussion. The level of cytokines and indicators of the hemostatic system depended on the severity of the disease. In patients of the 1st group in the acute period of the disease, the levels of pro-inflammatory cytokines IL-1β, IL-6, IL-8 and TNF-α were higher than in patients of the 2nd group. The decrease in the IFNγ content mainly occurred in patients of the 1st group. The level of interleukins in acute pneumonia was higher than bronchitis, 4,1 times in acute pneumonia, 1,5 times higher in acute bronchitis than in control. Conclusion. Homeostasis indicators in patients with acute complicated pneumonia living in adverse environmental regions and conditions and having acute pneumonia, showed higher rates of fibrinogen, indicating that the hemostasis system had a high degree of readiness for intravenous blood clotting, hypo-hypercoagulation, thrombinemia, and fibrinolysis. Younger children are characterized by severe and complicated complications of acute pneumonia and bronchitis, as well as compensatory hypercoagulation in the hemostasis system, subcompensative hypercoagulation, decompensation hypercoagulation (hypercoagulation hypocoagulation, various hemorrhages).

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