Central Asian Journal of Medicine


Introduction. Early diagnosis of sepsis allows to make a diagnosis on time, correctly assess the condition of young children, and start timely treatment. The article analyzes the diagnostic potential of new early marker like procalcitonin. Material and methods. The research involved 82 children with the diagnosis of sepsis, severe sepsis, or septic shock, who were under observation in the Tashkent Medical Academy. The study population constituted all children from newborns to 3 years old patients. All patients were divided into documented bacterial (n=22) versus abacterial inflammation (n=60) infections in order to assess serum PCT concentrations with a cutoff value of >0.5 ng/mL. The traditionally widely used biomarkers of sepsis are cytokines, CRP and PCT. Results and discussion. In the process of sepsis monitoring, procalcitonin unlike other markers, reliably reflects the real dynamics of its severity, quickly and adequately changes depending on the effectiveness of therapy, predicts relapses of sepsis after remission, when the clinical signs of sepsis and procalcitonin levels normalize. With surgical pathology, injuries and burns in the absence of an infection, procalcitonin does not increase. Early diagnosis of sepsis is difficult issue in pediatric practice, whilst it can be vital for positive patient outcomes in sepsis management. Any delay in diagnosis and treatment may bring on multiple organ failure and can be hazardous with elevated mortality consequences. Early diagnosis and effective management of sepsis not only gives an opportunity for prompt antibiotic therapy and a potential decrease in mortality, it can also belittle the unnecessary use of antibiotics. Conclusion. A review of the results of international and domestic studies suggest that procalcitonin is an effective method for the early diagnosis and monitoring of systemic infections of young children.

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