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Central Asian Journal of Medicine

Abstract

Backgrounds. Colorectal cancer (CRC) incidence has a tendency to increase in recent decades in many countries of the world. The present research explores the data on indications for organ-preserving operations in the CRC and analyzes new criteria for their implementation. Materials and research methods. A retrospective analysis of the clinical data of 120 patients with colorectal cancer (CRC) with a T3-4N0-1M0 stage of the disease was carried out, who were observed in the Oncoproctology Department of RSSPMCO and the Ministry of Health Care of Republic of Uzbekistan in the period from 2005 to 2015. Patients were divided into the main and control clinical groups. The main group included 60 patients with RC who underwent various types of operations during complex treatment: abdominal-anal resection of the rectum (AARR), anterior resection of the rectum (ARR), Hartmann's operation. The control group included 60 patients with RC who underwent abdominal-perineal extirpation of the rectum (APER). Results and discussion. The results of organ-preserving operations in the complex treatment of CRC were observed during three and five years. Cases of relapses and metastases were analyzed, and the survival of patients over a three- and five-year period was evaluated, depending on prognostic factors. During the three-year observation, local relapses in the main group occurred in 10 (16.6%) patients with RC and in the control group in 13 (21.7%) patients. The average relapse rate was 11,82,4 months. Conclusion. A new method has been developed for the complex treatment of patients with CRC, including preoperative high-dose hypoxiradiotherapy, followed by organ-conserving operations. Besides a new approach has been developed for the complex treatment of patients with CRC, including preoperative endolymphatic polychemotherapy and regional lymphatic polychemotherapy, as well as in combination with hypoxiradiotherapy.

First Page

172

Last Page

189

References

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