•  
  •  
 

Central Asian Journal of Medicine

Abstract

Research objective. Under conditions of unilateral ureter occlusion, development of microhemodynamic disorders of cortical substance in kidneys was studied both on the damage side and on contralateral (opposite) side. Materials and methods. Under the conditions of the experiment, we studied the state of microhemodynamics of the cortical region of both kidneys during the development of unilateral hydronephrosis. The experiments were conducted on 90 (48 experimental, 36 false-operated, 6 intact) outbred adult males. Results. It has been established that disorders on the side of occlusion depend on duration of obstruction in lumen of ureter, which determines the development of tissue hypoxia and violates trophic renal parenchyma. Conclusion. Dynamically functional disorders of the microvasculature occur at the early (on the 1st, 3rd, and 5th day), and irreversible changes in the renal parenchyma at the later (on the 14th and 30th day) stages of the experiment. The contralateral one responds to turning off the function of one kidney by adaptive restructuring of the microhemocirculatory system, which is manifested by micro vessels dilatation and an increase in the linear velocity of blood flow in them, which ensures its hyperfunction.

First Page

81

Last Page

89

References

1. Yazıcı M, Celebi S, Kuzdan Ö, Koçan H, Ayyıldız HS, Bayrak İK, Bilgici MC, Yapıcı O, Kefeli M, Arıtürk E. Current radiological techniques used to evaluate unilateral partial ureteral obstruction: an experimental rabbit study. Int Urol Nephrol 2015;47:1045-50. 10.1007/s11255-015-0998-9 2. Parida GK, Tripathi M, Kumar K, Damle N. Objective improvement in renal function post-Dietl's crisis: Documented on renal dynamic scintigraphy. Indian J Nucl Med 2016;31:240-1. 10.4103/0972-3919.181527 3. Fink RL, Caridis DT, Chmiel R, Ryan G. Renal impairment and its reversibility following variable periods of complete ureteric obstruction. Aust N Z J Surg 1980;50:77-83. 10.1111/j.1445-2197.1980.tb04502.x 4. Schweitzer FA. Intra-pelvic pressure and renal function studies in experimental chronic partial ureteric obstruction. Br J Urol 1973;45:2-7. 10.1111/j.1464-410X.1973.tb06999.x 5. Maenhout A, Ham H, Ismaili K, Hall M, Dierckx RA, Piepsz A. Supranormal renal function in unilateral hydronephrosis: does it represent true hyperfunction? Pediatr Nephrol 2005; 6. Ajmi S, Ben Ali K, Guezguez M, Sfar R, Nouira M. Captopril renography as a prognostic factor in obstructive hydronephrosis with preserved renal function. Rev Esp Med Nucl 2010;29:20-4. 10.1016/j.remn.2009.09.004 7. Claesson G, Svensson L, Robertson B, Josephson S, Cederlund T. Experimental obstructive hydronephrosis in newborn rats. XI. A one-year follow-up study of renal function and morphology. J Urol 1989;142:1602-7. 10.1016/S0022-5347(17)39177-2 8. . Hegarty N.J., Young L.S., Kirwan C.N., O’Neill A.J., Bouchier-Hayes D.M., Sweeney P. Nitric oxide in unilateral ureteral obstruction: effect on regional renal blood flow. Kidney Int. 2001;59:1059–1065. 9. Karam M., Feustel P.J., Goldfarb C.R., Kogan B.A. Diuretic renogram clearance half-times in the diagnosis of obstructive uropathy: effect of age and previous surgery. Nucl Med Commun. 2003; 10. Chade A.R., Rodriguez-Porcel M., Herrmann J., Zhu X., Grande J.P., Napoli C. Antioxidant intervention blunts renal injury in experimental renovascular disease. J Am Soc Nephrol. 2004; 11. Chevalier R.L., Chung K.H., Smith C.D., Ficenec M., Gomez R.A. Renal apoptosis and clusterin following ureteral obstruction. The role of maturation. J Urol. 1996;156:1474–1479 12. Chevalier R.L., Chung K.H., Smith C.D., Ficenec M., Gomez R.A. Renal apoptosis and clusterin following ureteral obstruction. The role of maturation. J Urol. 1996;156:1474–1479 13. Goligorsky, M.S., Chen, J. and Brodsky, S., 2001. Workshop: endothelial cell dysfunction leading to diabetic nephropathy: focus on nitric oxide. Hypertension, 37(2), pp.744-748. 14. Alioua, N., Amine, A., Rogozan, A., Bensrhair, A. and Rziza, M., 2016. Driver head pose estimation using efficient descriptor fusion. EURASIP Journal on Image and Video Processing, 2016(1), p.2. 15. Bakhtiyari, K., Taghavi, M. and Husain, H., 2015. Hybrid affective computing—keyboard, mouse and touch screen: from review to experiment. Neural Computing and Applications, 26(6), pp.1277-1296. 16. J. Su, Y. Liu, and J. Wang, “Ultrasound image assisted diagnosis of hydronephrosis based on CNN neural network,” J. King Saud Univ. - Sci., 2020. 17. Cai, X. R., Zhou, Q. C., Yu, J., Feng, Y. Z., Xian, Z. H., Yang, W. C., & Mo, X. K. 2015. Assessment of renal function in patients with unilateral ureteral obstruction using whole-organ perfusion imaging with 320-detector row computed tomography. PloS one, 10(4), e0122454. 18. Hope A, Clausen G. Renal blood flow during unilateral ureteral obstruction. Effects of reduced perfusion pressure, acetylcholine, and thromboxane A2 blockers in obstructed and unobstructed rat kidneys. Acta Physiol Scand. 1983;119(4):327-334. doi:10.1111/j.1748-1716.1983.tb07348.x 19. Hope A, Clausen G, Rosivall L. Total and local renal blood flow and filtration in the rat during reduced renal arterial blood pressure. Acta Physiol Scand. 1981;113(4):455-463. doi:10.1111/j.1748-1716.1981.tb06922.x 20. Jad Khaled AlSmadi, Xiaohang Li, Guohua Zeng, Use of a modified ureteral access sheath in semi-rigid ureteroscopy to treat large upper ureteral stones is associated with high stone free rates, Asian Journal of Urology, Volume 6, Issue 3, 2019, Pages 217-221.

Share

COinS
 
 

To view the content in your browser, please download Adobe Reader or, alternately,
you may Download the file to your hard drive.

NOTE: The latest versions of Adobe Reader do not support viewing PDF files within Firefox on Mac OS and if you are using a modern (Intel) Mac, there is no official plugin for viewing PDF files within the browser window.