Central Asian Journal of Medicine


In this study, a comprehensive research of the phagocytic activity of neutrophils in patients with heroin addiction was carried out. It was found that heroin addiction is accompanied by pronounced changes in the cellular-humoral defense system of the body. Opiate substances have a mainly suppressive effect on immunocompetent cells. The disorganization of the immune systems, which are closely interconnected with the central nervous system, leads to disruption of cellular and humoral homeostasis and aggravates the process of drug addiction. One of the existing hypotheses of the cause of this process is the theory of a decrease in the function of immunocytes under the damaging effect of heroin on the human body. Research objective: The aim of this study is to determine the phagocytic activity of neutrophils in patients with heroin addiction. Materials and methods. The total number of patients was 57 (43 men and 14 women), whose age varied from 23 to 34 years. Results. Analysis of the anamnestic data of drug addicts revealed a tendency to infectious diseases, while chronic infections were predominant – sinusitis. At the end of pharmacotherapy, patients of the 1st group noted an improvement in their condition, a decrease in the symptoms of pathological craving for alcohol, and returned to their familiar social environment. Conclusion. Summary: Based on a comprehensive study of the phagocytic activity of neutrophils in patients with heroin addiction, it was found that heroin addiction is accompanied by pronounced changes in the cellular-humoral defense system of the body.

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