Central Asian Journal of Medicine


Hepatitis Delta is severe and rapidly progressing form of viral hepatitis which leading to the liver cirrhosis and this infection is still an unresolved global health problem. The treatment of delta-virus infection is an unresolved problem. The application of the interferon preparations in case of delta-infection does not guarantee the efficacy of the treatment in the majority of patients, does not provide the stability of the elimination of the virus and gives a set of side-effects. New preparations with other mechanisms of the actions are now developing. These are nucleosides analogues and preparations with the specific mechanisms of action like Myrcludex B, Lonafarnib, REP 2139 which are in process of clinical tests. The combined therapy by the interferons and the nucleoside analogues seems to be perspective.

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