•  
  •  
 

Central Asian Journal of Medicine

Abstract

Aim: to evaluate the effectiveness of new domestic drugs (cavergal, geranyl and catacin) in the correction of the main hepatic syndromes: cytolysis, cholestasis, mesenchymal inflammation and hepatocellular insufficiency in a model of toxic liver damage. Material and methods: studies were conducted on 75 male rats with acute toxic liver damage, which was reproduced by administering heliotrin at a dose of 200 mg/kg, 8 rats were included into intact group. Biochemical studies of blood serum were performed on a biochemical analyzer. Result: experimental pharmacotherapy of acute toxic liver damage with new drugs katatsin and geranil significantly reduced rates of cytolysis, cholestasis, mesenchymal inflammation. The preparations increased the protein synthesis function of the liver. According to hepatoprotective properties, catacin and geranil were not inferior to Karsil to the hepatoprotector and significantly outperformed the antihypoxant of the cavergal. Conclusion: the plant flavonoids catacin and geranyl have pronounced hepatoprotective properties.

First Page

119

Last Page

124

References

1. Abdullayev G.R. Vliyaniye katatsina na protsessi` perekisnogo okisleniya lipidov organov kri`s v dinamike razvitiya stressa // Uzbekskiy biol. jurn. – 2016. – №3. – S. 7-11. 2. Azarova О.V., Galaktionova L.P. Flavonoidi`: Mekhanizm protivovospalitel`nogo deystviya // Khimiya rastitel`nogo si`r`ya. – 2012. – №4. – S. 61-78. 3. Almatov К.Т., Abdullayev G.R. Izmeneniya energeticheskogo metabolizma mitokhondriy pecheni kri`s v dinamike razvitiya khronicheskogo emotsional`nogo-bolevogo stressa i ikh korrektsii katatsinom // Uzbekskiy biol. jurn. – 2016. – №2. – S. 20-26. 4. Dorkina Ye.G. Izucheniye gepatozashitnogo deystviya prirodni`kh flavonoidni`kh soyedineniy // Eksper. i klin. farmakol. – 2004. – №6. – S. 41-44. 5. Zverev Ya.F. Flavonoidi` glazami farmakologa. Antioksidantnaya i protivovospalitel`naya aktivnost` // Obzori` po klin. farmakol. i lekarstvennoy terapii. – 2017. – Т. 15, №4. – S. 5-15 6. Mekhtiyev S.N., Onkoviti`y S.V., Mekhtiyeva О.А. Printsipi` vi`bora gepatoprotektorov v praktike terapevta // Lech. vrach. – 2016. – №8. – S. 44-53. 7. Nazrullayev А.М., Mirzaakhmedov B.М. Issledovaniye khronicheskoy toksichnosti preparata katatsin // Uzbekskiy biol. jurn. – 2016. – №2. – S. 26-29. 8. Narbutayeva D.А., Khushbaktova Z.А. Izucheniye deystviya proantotsianidina geranila v sravnenii s kavergalom i katatsinom pri okklyuzii sosudov mozga u kri`s // Integratsiya obrazovaniya, nauki i proizvodstva v farmatsii. – Tashkent, 2014. – S. 279-280. 9. Novikov V.Ye., Klimkina Ye.I. Farmakologiya gepatoprotektorov // Obzori` po klin. farmakol. i lekastvunnoy terapii. – 2005. – Т. 4, №1. – S. 2-20. 10. Skakun N.P., Shmam`ko V.V., Okhrimovich L.M. Klinicheskaya Farmakologiya gepatoprotektorov. – Ternopol`: Zbruch, 1995. – 272 s. 11. Tarakhovskoy Yu.S., Kim Yu.А., Abdrasilov B.S., Muzafarov Ye.N. Flavonoidi`: biokhimiya, biofizika, meditsina. – Pushino: Synchrobook, 2013. 12. Ushkalova Ye.А. Problemi` primeneniya gepatoprotektorov // Farmateka. – 2004. – № 4. – S. 45-55. 13. Sherlok Sh., Duli Dj. Zabolevaniya pecheni i jelchni`kh putey. – М.: GEOTAR-Мedia, 1999. – 864 s. 14. Shirinova I.А., Nuridinov Sh.Sh., Klemesheva L.S., Almatov К.Т. Vliyaniye katatsina na obmen lipidov v krovi i pecheni kri`s // Uzbekskiy biol. jurn. – 2009. – №3. – S. 7-11. 15. Agati G., Azzarello E., Pollastri S., Tattini M. Flavonoids as antioxidants in plants: location and functional significance // Plant. Sci. – 2012. – Vol. 196. – Р. 67-76. 16. Ayala A., Muñoz M.F., Argüelles S. Lipid Peroxidation: Production, Metabolism Signaling Mechanisms of Malondialdehyde and 4-Hydroxy-2-Nonenal // Oxidat. Med. Cell. Long. – 2014. – Vol. 31. 17. Ferdinando M.D., Brunetti C., Fini A. Tattini M. Flavonoids as antioxidants in plants under abiotic stresses // Abiotic Stress Responses in Plants: Metabolism, Productivity and Sustainability. – N.Y.: Springer, 2012. – Р. 159-179. 18. Karimov Kh.Ya., Inoyatova F.H., Karabanovich A.K. Correction of disorder of the liver microcirculation and functionally-metabolic parameters of rats with acute toxic hepatitis // The International Toxicologist Abstracts of the International Congress of Toxicology-VII. – Seattle; Waschington, 1995. – P. 13. 19. Kumar Sh., Pandey A.K. Chemistry and Biological Activities of Flavonoids: An Overview (Review Article) // Sci. Wld J. – 2013. – Vol. 16. 20. Mishra A., Kumar Sh., Bhargava A. et al. Studies on in vitro antioxidant and antistaphylococcal activities of some important medicinal plants // Cell. Mol. Biol. – 2011. – Vol. 57, №1. – Р. 16-25.

Share

COinS