Central Asian Journal of Medicine


Objective: To study the metabolism of lipids in relation to structural changes in adipose tissue in rats with prenatal hyperandrogenism. Material and Methods: The studies carried out on 90 outbred white pregnant female rats on a normal laboratory diet. On the 15th day of pregnancy, the rats were divided into 3 groups: the 1st - 30 animals (intact group), the 2nd - 30 pregnant rats, receiving sesame oil 0.5 ml from the 16th to the 19th day of pregnancy 100 g of weight (comparison group), 3rd - 30 pregnant rats from the 16th to the 19th day of pregnancy, which were given subcutaneously with 5 mg / kg of free T (T-1500; Sigma) dissolved in 100 ml of sesame oil in the period 16– 19 days of gestation (main group, hyperandrogenization). Results: prenatal androgenization leads to an increase in body weight, parameters of subcutaneous fat, the formation of obesity in the offspring. Metabolic disorders are manifested by dyslipidemia IV and V types and obesity. This is more pronounced in the offspring, with a highcalorie diet. Conclusions: One of the main mechanisms of metabolic changes in rats subjected to prenatal androgenization may be associated with an increased diet and/or reduced energy expenditure, leading to an increase in obesity.

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