•  
  •  
 

Central Asian Journal of Medicine

Abstract

Objective: To study the metabolism of lipids in relation to structural changes in adipose tissue in rats with prenatal hyperandrogenism. Material and Methods: The studies carried out on 90 outbred white pregnant female rats on a normal laboratory diet. On the 15th day of pregnancy, the rats were divided into 3 groups: the 1st - 30 animals (intact group), the 2nd - 30 pregnant rats, receiving sesame oil 0.5 ml from the 16th to the 19th day of pregnancy 100 g of weight (comparison group), 3rd - 30 pregnant rats from the 16th to the 19th day of pregnancy, which were given subcutaneously with 5 mg / kg of free T (T-1500; Sigma) dissolved in 100 ml of sesame oil in the period 16– 19 days of gestation (main group, hyperandrogenization). Results: prenatal androgenization leads to an increase in body weight, parameters of subcutaneous fat, the formation of obesity in the offspring. Metabolic disorders are manifested by dyslipidemia IV and V types and obesity. This is more pronounced in the offspring, with a highcalorie diet. Conclusions: One of the main mechanisms of metabolic changes in rats subjected to prenatal androgenization may be associated with an increased diet and/or reduced energy expenditure, leading to an increase in obesity.

First Page

90

Last Page

101

References

1. Serov V.N., Prilepskaya V.N., Ovsyannikova T.V. Giperandrogeniya v ginekologii // Ginekologicheskaya endokrinol. – 5-ye izd. – M.: MEDpress-inform, 2015. – 512 s. 2. Khaydarova F.A. Patogeneticheskiye mekhanizmy formirovaniya sindroma polikistoznykh yaichnikov i obosnovaniye differentsirovannogo podkhoda k yego lecheniyu: Dis. … d-ra med. nauk. – Tashkent, 2009. – 234 s. 3. Khaydarova F.A., Maksudova F.T. Ozhireniye i reproduktivnoye zdorov'ye zhenshchin: Metod. rekomendatsii. – Tashkent, 2012. – 44 s. 4. Shustov S.B., Baranov V.L., Khalimov YU.SH. Klinicheskaya endokrinologiya. – M.: Med. inform. agentstvo, 2012. – 632 s. 5. Abbott D.H., Bacha F. Ontogeny of polycystic ovary syndrome and insulin resistance in utero and early childhood // Fertil. Steril. – 2013. – Vol 100, №1. 6. de Melo A.S., Vilan Dias S., de Carvalho Cavalli R. et al. Pathogenesis of polycystic ovary syndrome: multifactorial assessment from the foetal stage to menopause // Reproduction. – 2015. 7. Demissie M., Lazic M., Foecking E.M. et al. Transient prenatal androgen exposure produces metabolic syndrome in adult female rats // Amer. J. Physiol. Endocrinol. Metab. – 2008. – Vol. 295, №2. – P. E262-E268. 8. Duffy J.M., Ahmad G., Mohiyidden L. Growth hormone for in vitrofertilization // Cochrane Datab. Syst. Rev. – 2010. – Vol. 1. – P. 215-220. 9. Heber M.F., Ferreira S.R., Velez L.M., Motta A.B. Prenatal hyperandrogenism and lipid profile during different age stages: an experimental study // Fertil. Steril. – 2013. – Vol. 2. – P. 551-557. 10. Levente S., Antal P., Masszi G. et al. Arteriolar insulin resistance in a rat model of polycystic ovary syndrome // Fertil. Steril. – 2012. – Vol. 97. – P. 462-468. 11. Linne Y. Effects of obesity on women's reproduction and complications during pregnancy // Obesity rev. – 2004. – Vol. 5. – P. 137-143. 12. Padmanabhan V., Veiga-Lopez A. Animal models of the polycystic ovary syndrome phenotype // Steroids. – 2013. – Vol. 78. – P. 734-740. 13. Steculorum S.M., Vogt M.C., Bruning J.C. Perinatal Programming of Metabolic Diseases // Endocrinol. Metab. Clin. North Amer. – 2013. – Vol. 42. – P. 149-164. 14. Sunkara S.K., Pundir J., Khalaf Y. Effect of androgen supplementation or modulation on ovarion stimulation outcome in poor responders:a meta-analysis // Reprod. Biomed. Online. – 2011. – Vol. 22. – P. 545-555. 15. Xiao-Yan W.U., Zhi-Ling L.I., Cheng-Yong W.U. et al. Endocrine Traits of Polycystic Ovary Syndrome in Prenatally Androgenized Female Sprague-Dawley Rats // Endocrine J. – 2010. – Vol. 57, №3. – P. 201-209.

Share

COinS