Central Asian Journal of Medicine


Objective: of the study was to study the effect of kavergal on the parameters of carbohydrate and lipid metabolism in rabbits with a metabolic syndrome. Material and methods. Experiments were performed on 18 rabbits. The model of metabolic syndrome was reproduced according to H.Ya.Karimov s recommendations. In the course of treatment a significant decrease in the level of TG, VHDL and glucose of blood in rabbits treated with cavergal. In contrast to mildronate, cavergal showed a stronger lipid-lowering effect. Conclusion: The results of the study indicate a favorable effect of the cavernal both on the lipid spectrum of the blood and on the degree of hyperglycemia.

First Page


Last Page



1. Garets V. I., Fedchenko N. P., Koncha L. I. Sposob modelirovaniya ateroskleroza. Patent RU 2033646 S1 (2001). 2. Karimov KH. YA., Mukhammedov KH. A., Yuldashev N. M., Saidov S.A. Sposob modelirovaniya metabolicheskogo sindroma u krolikov. Patent (IAP 20050314) RUz (2006). 3. Kravchuk Ye.N., Galagudza M.M. Eksperimental'nyye modeli metabolicheskogo sindroma // Arterial'naya gipertenziya. - 2014. - №5. - S.379-383. 4. Metabolicheskiy sindrom: eksperiment, klinika, terapiya // Materialy III Mezhdunarodnogo simpoziuma., Grodno, 2017. – S.204 - 212 5. Nikishin A.G. i dr. Effekty antioksidanta kavergala u bol'nykh s infarktom miokarda, poluchavshikh streptokinazu // Vestnik ekstrennoy meditsiny. - 2009. - №4. - S.33-37. 6. Shmerko Ye.P. i dr. Diyetofitoterapiya v profilaktike faktorov riska metabolicheskogo sindroma // Metabolicheskiy sindrom: eksperiment, klinika, terapiya: sb. nauch. st. NAN Belarusi; redkol.: L.I. Nadol'nik (gl. red.) – Grodno: GrGU, 2015. – S. 255-258. 7. Fellman L., Nascimento A.R., Tibirica E. et al. Murine models for pharmacological studies of the metabolic syndrome // Pharmacol. Ther.-2013.-Vol. 137, №3.-P.331-340. 8. Grigorjeva ME, Myasoedov NF, Lyapina LA, Obergan TY, Andreeva LA. The Status of the Hemostasis System under the Influence of Proline Peptides during the Development of Experimental Metabolic Syndrome // Dokl Biochem Biophys. - 2018 Mar. – Vol.479. – P. 59-61.



To view the content in your browser, please download Adobe Reader or, alternately,
you may Download the file to your hard drive.

NOTE: The latest versions of Adobe Reader do not support viewing PDF files within Firefox on Mac OS and if you are using a modern (Intel) Mac, there is no official plugin for viewing PDF files within the browser window.