Central Asian Journal of Medicine


Objective: Meta-nalysis of review of the recent epidemiology of stroke in some Asian countries, including burden, registry, mortality, incidence, prevalence, stroke subtypes and risk factors. Materials and Methods: We analyzed all the publications in the PubMed, Medline, Scopus, ScienceDirect, Web of Science, EBSCO, Google Scholar databases, from the time of entry into the database until March 2018. Results: Based on data from the WHO, GBD study, recent publications from Asian countries and our own studies, we summarized and compared the main epidemiological data on stroke in Asia, including Uzbekistan. With the economic transition of these countries, towards achieving “developed country” status, risk factors such as hypertension, diabetes mellitus, hypercholesterolemia, obesity, and cigarette smoking will become more prevalent, raising the incidence of stroke. However, due to insufficient healthcare facilities in these developing countries, the mortality will be high, and the number of disabled survivors will also rise. Conclusion: The global burden of stroke has the largest contribution from Asia. As life expectancy increases, with the aging of Asian populations and reduction in mortality due to infectious diseases, and the rise in the prevalence of vascular risk factors among economies in transition, the stroke burden in Asia will surely rise. Governments and healthcare workers need to work together, with an informed public, to stem this growing epidemic.

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1. Adams H.P., Bendixen B.H., Kappelle L.J. et al. Classification of subtype of acute ischemic stroke. Definitions for use in a multicenter clinical trial. TOAST. Trial of Org 10172 in Acute Stroke Treatment // Stroke. – 1993. – Vol. 24 (1). – P. 35-41. 2. Azhieva Z.B. Dynamics and prognosis of the incidence of cerebral strokes, according to registry of Nukus city // Neurology (Uzbekistan). – 2008. – No. 3-4. – P. 44. In Russian. 3. Byung N.V., Yoon W., Pandian J., Navarro J.C. Stroke Epidemiology in South, East, and South-East Asia: A Review // J. Stroke. – 2017. – Vol. 19 (3). – P. 286-294. 4. Erkebaeva S.K., Nurguzhaev E.S., Gafurov B.G., Zharkinbekova N.A., Abasova G.B. Epidemiology and climate and geographic risk factors of stroke in the South Kazakhstan region // Zh. Nevrol. Psikhiatr. Im. S.S. Korsakova. – 2013. – Vol. 113 (3 Pt 2). – P. 3-8. In Russian. 5. Feigin V.L., Forouzanfar M.H., Krishnamurthi R., Mensah G.A. et al. Global Burden of Diseases and Risk Factors Study 2010 (GBD 2010) and the GBD Stroke Experts Group Global and regional burden of stroke during 1990-2010: findings from the Global Burden of Disease Study 2010. // Lancet. – 2014. – Vol. 383. – P. 245-254. 6. Feigin V.L., Krishnamurthi R.V., Parmar P., Norrving B. et al. GBD 2013 Writing Group. GBD 2013 Stroke Panel Experts Group Update on the Global Burden of Ischemic and Hemorrhagic Stroke in 1990-2013: the GBD 2013 study // Neuroepidemiology. – 2015. – Vol. 45. – P. 161-176. 7. Gafurov B.G. The rate and clinical structure of cerebral strokes in Uzbekistan based on hospital registry // Report in Scientific Conference: Relevant problems in Surgery Tashkent, 2009. In Russian. 8. Hashmi M., Khan M., Wasay M. Growing burden of stroke in Pakistan: a review of progress and limitations // Int. J. Stroke. – 2013. – Vol. 8. – P. 575-581. 9. Hong K.S., Bang O.Y., Kang D.W., Yu K.H. et al. Stroke statistics in Korea: part I. Epidemiology and risk factors: a report from the Korean stroke society and clinical research center for stroke // J. Stroke. – 2013. – Vol. 15. – P. 2-20. 10. Kim A.S., Johnston S.C. Global variation in the relative burden of stroke and ischemic heart disease // Circulation. – 2011. – Vol. 124. – P. 314-323. 11. Kim J.S. Stroke in Asia: a global disaster // Int. J. Stroke. – 2014. – Vol. 9. – P. 856–857. 12. Krishnamurthi R.V., Moran A.E., Forouzanfar M.H., Bennett D.A. et al. Global Burden of Diseases and Risk Factors 2010 Study Stroke Expert Group The global burden of hemorrhagic stroke: a summary of findings from the GBD 2010 study // Glob. Heart. – 2014. – Vol. 9. – P. 101-106. 13. Kusuma Y., Venketasubramanian N., Kiemas L.S., Misbach J. Burden of stroke in Indonesia // Int. J. Stroke. – 2009. – Vol. 4. – P. 379-380. 14. Mehndiratta M.M., Khan M., Mehndiratta P., Wasay M. Stroke in Asia: geographical variations and temporal trends // J. Neurol. Neurosurg. Psychiatry. – 2014. – Vol. 85. – P. 1308-1312. 15. Pandian J.D., Sudhan P. Stroke epidemiology and stroke care services in India // J. Stroke. – 2013. – Vol. 15. – P. 128-134. 16. Rasulova H.A. Risk factors in different stroke subtypes (Tashkent hospital based study) // Vestnik TMA. – 2013. – No. 3. – P. 120-128. 17. Rasulova Kh.A. Preliminary findings of Tashkent hospital based study of risk factors for different ischemic stroke subtypes // European Medical, Health and Pharmaceutical Journal. – 2014. – Vol. 7 (2). – P. 26-33. 18. Rasulova Kh.A., Usmanova D.D. Optimization of method of differential diagnosis of pathogenic subtypes of ischemic stroke: Methodical recommendations. – Tashkent, 2015. – 36 p. In Russian. 19. Sagatov D., Rasulova K., Madjidova Y. Risk factors and prognosis of ischemic stroke in young patients in Uzbekistan // Medical and Health Science Journal. –2011. – Vol. 5. – P. 16-22. 20. Sun H., Zou X., Liu L. Epidemiological factors of stroke: a survey of the current status in China // J. Stroke. – 2013. – Vol. 15. – P. 109-114. 21. Suslina Z.A., Varakin Y.A., Vereschagin N.V. Brain vascular diseases: Epidemiology. Pathogenic mechanisms. Prevention. – Moscow, 2009. In Russian. 22. Suwanwela N.C. Stroke epidemiology in Thailand // J. Stroke. – 2014. – Vol. 16. – P. 1-7. 23. Toyoda K. Epidemiology and registry studies of stroke in Japan // J. Stroke. –2013. – Vol. 15. – P. 21-26. 24. Turgumbaeva J.D., Akynbekov K.U., Turgumbaev D.D. The structure of the incidence and risk factors of stroke in Bishkek according to the register // Vestnik KazNMU. – 2015. – No. 3. – P. 92-96. In Russian. 25. Vereschagin N.V., Suslina Z.A. Determination of the probabilities of stroke subtypes 2004 www.stroke-center.ru. In Russian. 26. World Health Organization 2018 http://www.who.int/gho/countries/en/. 27. Xu G., Ma M., Liu X., Hankey G.J. Is there a stroke belt in China and why? // Stroke. – 2013. – Vol. 44. – P. 1775-1783. 28. Yoshida D., Ninomiya T., Doi Y., Hata J. et al. Prevalence and causes of functional disability in an elderly general population of Japanese: the Hisayama study // J. Epidemiol. – 2012. – Vol. 22. – P. 222-229. 29. Zhang C., Zhao S., Wang D., Wang Z., Jiang M. et al. An epidemiological study of stroke and its subtypes in the over 55 Mongolian and Han populations in a pastoral area of inner Mongolia // Int. J. Stroke. – 2011. – Vol. 6. – P. 468.