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Central Asian Journal of Medicine

Abstract

Objective: T o study the state of immune system in children with laryngeal papillomatosis, depending on the clinical course of the disease in dynamics of antiviral therapy. Materials and Methods: A comparative analysis of the immunological parameters in the dynamics (before and after) of standard therapy and after standard + immunotropic therapy was performed in 252 children with laryngeal papillomatosis aged from 3 to 9 years, who were examined and treated in the surgical department of otorhinolaryngology of TMA. Group 1 consisted of children with continuous-recurrent course of laryngeal papillomatosis: 1a subgroup - standard treatment (surgery) + IFN preparations (reaferon) - one course for 28 days; 1c subgroup - study group surgery + IFN preparations (α-IFN / inosine) - according to the scheme for 1 year; 2nd group - children with frequently recurrent laryngeal papillomatosis: 2a subgroup - standard treatment (surgery) + IFN preparations (reaferon) - one course for 28 days; 2c subgroup - surgery + preparations of IFN (α-IFN / inosine) - according to the scheme for 6 months; group 3 - children with rare recurrent course of laryngeal papillomatosis: 3a group - surgery; 3v group - surgery + lycopid. Results:, There were revealed unidirectional changes in the state of immune response in laryngeal papillomatosis, most pronounced in children with continuously recurrent form of laryngeal papillomatosis. In the dynamics of therapy, there was improvement in the cellular and humoral immunity, improvement in the clinical state of children, and decrease in the frequency of relapses. Conclusions: In complex treatment, using an inducer of interferon and lycopene leads to improvement in the parameters of the cellular and humoral units of immunity, in the dynamics there is improvement in the clinical state of children, decrease in the frequency of relapses.

First Page

35

Last Page

41

References

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