The test of quantitative evaluation of the state of liver parenchyma has been developed on the basis of different models of hepatocelluiar injuries induced by effect of CCL4, DL-galactosamine, mechanical jaundice, ischemia in the laboratory animals. The test was based on determination of the coefficient obtained due to studying of the activity of cytochromoxidase during the, presense of two substrates cytochrome С and TMFD in the organ tissue homogenate.
1. Dunaevsky O.A. Differential diagnosis of liver diseases.- / M., Medicine 1985.-262 p. 2. Podymova S.D. Liver diseases: Ruk. for doctors. - / M. Medicine, 1998.-704s. 3. Masevich CT, Ermolaeva L.G. Clinical, biochemical, morphological features of chronic hepatitis of various etiology // Therapeutic archive „-2002.-№ 2.-С.35-37. 4. Navruzbekov M.S. Assessment of the functional reserves of the liver and methods of predicted liver failure during operations on the liver / Abstract of the thesis for a candidate of medical sciences. M., 2009.-34 p. 5. Sakhipov S.Zh. Violation of the functional state and microcirculation of the liver with obstructive jaundice. / Diss. Ph.D. - M., 1983. - 162s. 6. Titov V.N. Biochemical methods for diagnosing liver pathology. // Therapeutic archive. - 1993, - No. 2.- P.85-89. 7. Trushanov A.A. Laboratory fabrication of a closed Clarke polarographic electrode. / In the book. Guidelines for the study of biological oxidation by the polarographic method. M.5 Science, 1973.- P.78-79. 8. Khazanov A.I. Functional diagnostics of liver diseases., - / M., Medicine, 1988. - 302 p.Ozawa Kazue/ Adaptive response of the liver mitochondrial and its relation to hepatic functional reserve. Evalution by cytochrome a (+ a 3) assay and glucosae intolerance //“Asian Med J”, 1980,23 №7, P.499-528. 9. Buechter, H., Zepp, R., & Gomer, G. (1990). The use of segmental anatomy for an operative classification of Liver injuries. //Ann. Sur., Vol.211, №6: 669-675.
Askarov, T.A.; Akhmedov, M.D.; Fayziev, Y.N.; Ashurmetov, A.M.; Dolimov, K.S.; and Аgzamova, М.N.
"MITOCHONDRIAL ENZYMS IN ASSESSMENT OF HEPATOCELLARY DAMAGES,"
Central Asian Journal of Pediatrics: Vol. 2021
, Article 1.
Available at: https://uzjournals.edu.uz/pediatrics/vol2021/iss1/1