During the study of the culture of isolated from pathological material taken from children with acute hemotogenic osteomyelitis and soft tissue infections, it was found that along with the considered main etiological factor of S. aureus, opportunistic enterobacteria and pseudomonas were also isolated (19.1% and 14.1% respectively). Of the isolated staphylococci, 66.5% were susceptible to the used antibiotics, conversely 61.3% of enterobacteria and 93.8% of proteas showed high resistance. Modern national and foreign literature indicates that significant changes occur in the etiology of purulent-inflammatory diseases, particularly, an increase in the proportion of opportunistic bacteria with the involvement of an increasingly wide range of microorganisms in the number of pathogens [2,4,8]. Therefore, tracking the species composition and determining the dominant species of microorganisms in the structure of purulent - inflammatory human diseases is still prevailing health problem [3,6,8].
1. Bazhenov L. G. Problems of overcoming antibiotic resistance of microorganisms // infection, immunity and pharmacology. -2000.-N 3. pp. 11-12. 2. Beloborodov B. R. Resistant gram-positive microorganisms: modern opportunities and prospects // Consilium medium. 2004.-Vol. 6. -N1. -pp. 4-11. 3. Otakhanov B. R. Indicators of occurrence of etiological agents in various surgical infections //infection, immunity and pharmacology. -2005. - No. 3. –pp. 42-43. 4. Sidorenko S. V. Research on the spread of antibiotic resistance: practical significance for medicine // infection and antimicrobial therapy. -2002. –T4. no. 21. –Pp. 5-11. 5. Coagulase-Negative staphylococci, clinical, microbiological and molecular features for predicting true bacteremia /P. Garcia, R. Benitez, Lam M. et al. // J. Micrjbiol Med. – 2004. No. 53. -Pp. 67-72. 6. Strachunsky LS, Reshedko GK, Eidelstein MV, Stetsyuk OU, Ryabkova EL, Andreeva AS, ROSNET research group. Comparative activity of cefepime and other antibiotics against nosocomial gram-negative infectious agents in Russia // Klin microbiol antimicrobial chemoter. - 2003. - No. 5 (3). – pp . 259–74. 7. Garnacho – Montero J., Garcia – Garmendia J., Barrero – Almodovar A. Impact of adequate empirical antibiotic therapy on the outcome of patients admitted to the intensive care unit with sepsis // Crit Care Med. - 2003. - vol. 31. - Pp. 2742–2751. 8. Lodise T.P., McKinnon P.S., Swiderski L., Rybak M.J. Outcomes analysis of delayed antibiotic treatment for рospital – acquired Staphylococcus aureus bacteremia // Clin Infect Dis. - 2003. - vol. 36. - Pp. 1418-1423. 9. Nasser S., Mabrouk A., Maher A. Colonization of burn wounds in Ain Shams University Burn Unit. // Burns. - 2003. - vol. 29 (3). - Pp. 229–323. 10. Osmon S., Ward S., Fraser V.J., Kollef M.H. Hospital mortality for patients with bacteremia due to Staphylococcus aureus or Pseudomonas aeruginosa // Chest. - 2004. - vol. 125. - Pp. 607-616. 11. Jacody G., Munoz-Price L., The new beta-lactamases // N Engi J Med 352 / -2005. -Pp.380-391.
Gafurova, N. S.; Mirzaeva, M.A.; and Atakhodjaeva, D. R.
"DETECTION OF RESISTANCE TO ANTIBIOTICS THE BACTERIA ISOLATED FROM CHILDREN WITH PURULENT-INFLAMMATORY DISEASES,"
Central Asian Journal of Pediatrics: Vol. 2020
, Article 10.
Available at: https://uzjournals.edu.uz/pediatrics/vol2020/iss3/10