In this study, a comprehensive research of the phagocytic activity of neutrophils in patients with heroin addiction was carried out. It was found that heroin addiction is accompanied by pronounced changes in the cellular-humoral defense system of the body. Opiate substances have a mainly suppressive effect on immunocompetent cells. The disorganization of the immune systems, which are closely interconnected with the central nervous system, leads to disruption of cellular and humoral homeostasis and aggravates the process of drug addiction. One of the existing hypotheses of the cause of this process is the theory of a decrease in the function of immunocytes under the damaging effect of heroin on the human body. Research objective: The aim of this study is to determine the phagocytic activity of neutrophils in patients with heroin addiction. Materials and methods. The total number of patients was 57 (43 men and 14 women), whose age varied from 23 to 34 years. Results. Analysis of the anamnestic data of drug addicts revealed a tendency to infectious diseases, while chronic infections were predominant – sinusitis. At the end of pharmacotherapy, patients of the 1st group noted an improvement in their condition, a decrease in the symptoms of pathological craving for alcohol, and returned to their familiar social environment. Conclusion. Summary: Based on a comprehensive study of the phagocytic activity of neutrophils in patients with heroin addiction, it was found that heroin addiction is accompanied by pronounced changes in the cellular-humoral defense system of the body.
1. Ghazavi A, Solhi H, Moazzeni SM, Rafiei M, Mosayebi G. Cytokine profiles in long-term smokers of opium (Taryak). J Addict Med. 2013;7(3):200–3. 2. Singhal PC, Kapasi AA, Franki N, Reddy K. Morphine-induced macrophage apoptosis: the role of transforming growth factor-beta. Immunology. 2000;100(1):57–62 3. Wang J, Kelschenbach J, Koodie L, Martin J. Modulation of Immune Function by Morphine: Implications for Susceptibility to Infection. Journal of Neuroimmune Pharmacology. 2006 Mar 1;1(1):77–89. Ref Type: Generic. 4. Wang J, Barke RA, Charboneau R, Roy S, Wang J, Barke RA, Charboneau R, Roy S. Morphine impairs host innate immune response and increases susceptibility to Streptococcus pneumoniae lung infection. J Immunol. 2005;174:426–434. 5. Williams J. P., Lambert D. G. Opioids and the neuroimmune axis // Brit. J. Anaesth. - 2005. - Vol. 94, No. 1. - P. 3-6. 6. Laub F, Lei L, Sumiyoshi H, Kajimura D, Dragomir C, Smaldone S, Puche AC, Petros TJ, Mason C, Parada LF, Ramirez F. Transcription factor KLF7 is important for neuronal morphogenesis in selected regions of the nervous system. Mol Cell Biol. 2005;25:5699–5711 7. Shavit Y, Depaulis A, Martin FC, Terman GW, Pechnick RN, Zane CJ, Gale RP, Liebeskind JC. Involvement of brain opiate receptors in the immune-suppressive effect of morphine. Proc Natl Acad Sci U S A. 1986 Sep;83(18):7114–7117. 8. Zurawski G, Benedik M, Kamb BJ, Abrams JS, Zurawski SM, Lee FD. Activation of mouse T-helper cells induces abundant preproenkephalin mRNA synthesis. Science. 1986 May 9;232 9. Kim SJ, Angel P, Lafyatis R, Hattori K, Kim KY, Sporn MB, Karin M, Roberts AB. Autoinduction of transforming growth factor beta 1 is mediated by the AP-1 complex. Mol Cell Biol. 1990;10:1492–1497. 10. Dragic T, Litwin V, Allaway GP, Martin SR, Huang Y, Nagashima KA, Cayanan C, Maddon PJ, Koup RA, Moore JP, Paxton WA. HIV-1 entry into CD4+ cells is mediated by the chemokine receptor CC-CKR-5 [see comments] Nature. 1996;381:667–673. 11. Wang J, Charboneau R, Balasubramanian S, Barke RA, Loh HH, Roy S. Morphine modulates lymph node-derived T lymphocyte function: role of caspase-3, -8, and nitric oxide. J Leuk Biol. 2001;70:527–536. 12. Platt DM, Rowlett JK, Spealman RD, Platt DM, Rowlett JK, Spealman RD. Discriminative stimulus effects of intravenous heroin and its metabolites in rhesus monkeys: opioid and dopaminergic mechanisms. J Pharmacol Exp Therapeut. 2001;299:760–767. 13. Bidlack JM, Khimich M, Parkhill AL, Sumagin S, Sun B, Tipton CM. Opioid receptors and signaling on cells from the immune system. Journal of Neuroimmune Pharmacology. 2006;1(3):260–269. Ref Type: Generic. 14. Chuang TK, Killam KF, Jr, Chuang LF, Kung HF, Sheng WS, Chao CC, Yu L, Chuang RY. Mu opioid receptor gene expression in immune cells. Biochem Biophys Res Comm. 1995;216:922–930. 15. Fiset ME, Gilbert C, Poubelle PE, Pouliot M. Human neutrophils as a source of nociceptin: a novel link between pain and inflammation. Biochem. 2003;42:10498–10505.
Sultanov, Sh. Kh.; Ashurov, Z. Sh.; Khodzhaeva, N. I.; Shadmanova, L. Sh.; and Lyan, E. M.
"CLINICAL EVALUATION OF FUNCTIONAL STATE OF IMMUNE SYSTEM PARTUCULAR COMPONENTS IN PATIENTS WITH OPIUM ADDICTION,"
Central Asian Journal of Pediatrics: Vol. 2020
, Article 5.
Available at: https://uzjournals.edu.uz/pediatrics/vol2020/iss2/5