Central Asian Journal of Pediatrics

Central Asian Journal of Pediatrics


The aim of study was to research long-term hepatic morphofunctional adaptations of rats being undegone to various doses of silicon in experimental conditions. The materials were 22 male Wistar rats weighing 250-280 grams (256.8 ± 3.44 g) at the age from 4 to 7 months. All experimental proce-dures were carried out according to the requirements of International Rules for Treatment Animals. The research protocol was approved by the Ethics Committee of the Ministry of Health in the Republic of Uzbekistan. Silicon chloride (SiCl4) being used forexperiment was dissolved in distilled water and administered intraperitoneally (IP) in a single dose depending on the group of study. By the results of study, the silicon was extremely toxic bioactive heavy metal, which, even at low doses, was capable to disrupt liver homeostasis. At low and moderate doses the influence of silicon can cause morphofunc-tional pathological remodelling of liver parenchyma.

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