Central Asian Journal of Pediatrics

Central Asian Journal of Pediatrics


Despite such a well-developed medicine, the number of infertile couples increase every year and the problem of anovulation remains relevant. The solution to this problem is the induction of ovulation . Using of hormonal drugs, which stimulate ovulation, began in the second half of the 20th century. A serious complication of hormonal stimulation of the ovaries is hyperstimulated ovary syndrome (OHSS), which can be fatal. This syndrome was first described by Muller in the early 60s as a complication of ovulation stimulation using serum gonadotropins in mares in 1943 - as “massive ovarian hyperluteinization syndrome”. The first lethal outcome from ovarian stimulation and such complication as OHSS was recorded in 1951 from renal failure.

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