Despite such a well-developed medicine, the number of infertile couples increase every year and the problem of anovulation remains relevant. The solution to this problem is the induction of ovulation . Using of hormonal drugs, which stimulate ovulation, began in the second half of the 20th century. A serious complication of hormonal stimulation of the ovaries is hyperstimulated ovary syndrome (OHSS), which can be fatal. This syndrome was first described by Muller in the early 60s as a complication of ovulation stimulation using serum gonadotropins in mares in 1943 - as “massive ovarian hyperluteinization syndrome”. The first lethal outcome from ovarian stimulation and such complication as OHSS was recorded in 1951 from renal failure.
Kurbaniyazova, M.Z.; Matrizayeva, G.D.; Duschanova, Z.A.; and Saparbayeva, N.R.
"OVARIAN HYPERSTIMULATION SYNDROME - AS A COMPLICATION OF OVULATION INDUCTION,"
Central Asian Journal of Pediatrics: Vol. 2
, Article 23.
Available at: https://uzjournals.edu.uz/pediatrics/vol2/iss2/23