Central Asian Journal of Pediatrics

Central Asian Journal of Pediatrics


The article presents the clinical and experi mental evaluation of the inf luence of the drug L - arginine (Tivortin) on the process of apoptosis and endothelial function by flow_dependent vasodilation of the brachial artery in patients with cerebrovascular disease in the early stages of the process. A total of 20 patients with early manif estations of chronic cerebrovascular insufficiency. Statistically significant impact Tivortin dose equivalent daily dose of L - arginine 4 grams a day on the index induced apoptosis suggests the cytoprotective properties of the drug. Increasing the dose by half did not have an additional positive effect. Tivortin application of preventive treatment in patients with cardiovascular risk factors and signs of endothelial dysfunction suggests pathogenic focus of its activities.

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