"DEVELOPMENT AND VALIDATION OF SPECTROPHOTOMETRIC METHODS FOR ANALYSIS " by Zulaykho Asanalievna Smanova, Dilshod Davronbekovich Gapparov et al.

Scientific Bulletin of Namangan State University

Article Title

DEVELOPMENT AND VALIDATION OF SPECTROPHOTOMETRIC METHODS FOR ANALYSIS OF FRAMICETINE SULPHATE IN A MEDICINAL PRODUCT BEHIND

Authors

Zulaykho Asanalievna Smanova, Doctor of Chemical Sciences, prof. Department of Chemistry, NUUz, Tashkent.
Dilshod Davronbekovich Gapparov, Doctoral student of the Department of Chemistry of NUUz, Tashkent.
Fakhriddin Bakhronovich Isakulov, Applicant for the Department of Chemistry, National University of Uzbekistan, Tashkent, the Republic of Uzbekistan.

Abstract

A method is proposed for the quantitative determination of framycetin sulfate in the Framex preparation nasal spray 8000 IU / ml by spectrophotometry (SF). The developed method was validated by the following indicators: specificity, correctness, linearity, convergence and internal laboratory accuracy. It has been established that the developed methodology is valid for all characteristics and can be used for the quantitative determination of framycetin sulfate in the substances and composition of drugs.

First Page

109

Last Page

118

References

1. Federalnoe rukovodstvo dlya vrachey po ispolzovaniyu lekarstvennx sredstv (formulyarn. sist.). Vp. III. M.: GEOTAR-Media. 2002. 462 s. 2. Maychuk Yu.F. Optimizatsiya farmakoterapii vospalitelnx bolezney glaznoy poverxnosti // Rossiyskiy oftalmologicheskiy jurnal. 2008. № 3. S. 18–25. 3. Astaxova Yu.S., Riks I.A. Sovremenne metod diagnostiki i lecheniya kon'yunktivitov // SPb.: Izd–vo Sankt–Peterburgskogo meditsinskogo universiteta, 2007. 68 s. 4. Clarke`s analysis of drugs and Poisons / Edited by A. C. Moffat, M. D. Osselton and B. Widdop. – London: Pharmaceutical-Press, 2004. – 1632 p. 5. European Pharmacopoeia. 8th edition, volume 2.0. Framycetine sulfate. -Council of Europe, Strasbourg, 2014. p. 2305. 6. Rukovodstvo VOZ po trebovaniyam GMP – nadlejashey praktike organizatsii proizvodstva. Chast 2. Validatsiya., 1999 g. 7. FSP 42 Uz-26491354-2019 na preparat «Frameks» sprey nazalny 1,25 %, proizvoditel: OOO «Aseptica», g. Tashkent , 2019. 8. Klimenko, L. Yu. Analiz podxodov k opredeleniyu spetsifichnosti i selektivnosti pri provedenii validatsii analiticheskix metodik v sudebno-toksikologicheskom analize. // Ukr. med. alm. 2013. T. 16. №1. S. 47 – 49. 9. Klimenko L. Yu., Petyunin G. P., Kostina T. A. Podxod k opredeleniyu spetsifichnosti i selektivnosti pri validatsii UF-spektrofotometricheskix metodik kolichestvennogo opredeleniya v sudebno-toksikologicheskom analize // Farmatsiya Kazaxstana. 2013. №8. S. 53 – 56. 10. Klimenko L.Yu., Trut S.N., Petyunin G.P., Ivanchuk I.M. Modifikatsiya i validatsiya UF-spektrofotometricheskoy metodiki kolichestvennogo opredeleniya doksilamina v krovi: spetsifichnost // Ukr. jurn. klіn. ta laborator. meditsini. 2013. T. 8. №4. S. 191 – 199. 11. Klimenko, L. Yu. Approaches to determination of precision for UV-spectrophotometric methods of quantitative determination in forensic and toxicological analysis // Farmatsiya Kazaxstana. 2014. №3. S. 43 – 50. 12. Moffat A.C., Osselton M D., Widdop B. Clarke’s analysis of drugs and poisons in pharmaceuticals, body fluids and postmortem material. //London: Pharmaceutical Press, 2011. 2609 p. 13. Leontev D.A., Grizodub A.I. Metrologicheskiy kontrol kachestva rezultatov izmereniy // Farmakom. 2007. № 2. S. 16-25. 14. Grizodub A.I. Standartizovanne protsedur validatsii metodik kontrolya kachestva lekarstvennx sredstv // Farmakom. 2006. № 1/2. S. 35-44. 16. Georgievskiy V.P. Analiticheskaya ximiya v sozdanii, standartizatsii i kontrole kachestva lekarstvennx sredstv : v 3-x t. na russkom yazke // Izd. «NTMT», 2011.t. 2. 474 s. 17. Beregovx V.V. Validatsiya analiticheskix metodik dlya proizvoditeley lekarstv: tipovoe rukovodstvo predpriyatiya po proizvodstvu lekarstvennx sredstv // M.: Litterra, 2008. 132 s. 18. Derjavna farmakopeya Ukraїni // Derjavne pіdpriєmstvo «Naukovo-ekspertniy farmakopeyniy tsentr». Xarkіv: RІRYeG, dop. 4, 2011. 540 s. 19. Yakovenko V. K. Doslіdjennya yakіsnogo skladu preparatu kompleksnoї dії «Klіmased» // Zaporojskiy meditsinskiy jurnal. - 2011. 13, № 1. S. 98-101. 20. European Pharmacopoeia. - 6 th ed. Strasbourg : Council of Europe, 2007. 3261 p. 21. Barnes J. Herbal Medicines / Barnes J., Anderson L., Phillipson D. - 3-rd ed. L-n : PhP, 2007. 710 p.

Erratum

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Recommended Citation

Smanova, Zulaykho Asanalievna; Gapparov, Dilshod Davronbekovich; and Isakulov, Fakhriddin Bakhronovich (2020) "DEVELOPMENT AND VALIDATION OF SPECTROPHOTOMETRIC METHODS FOR ANALYSIS OF FRAMICETINE SULPHATE IN A MEDICINAL PRODUCT BEHIND," Scientific Bulletin of Namangan State University: Vol. 2 : Iss. 3 , Article 22.
Available at: https://uzjournals.edu.uz/namdu/vol2/iss3/22

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