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Scientific Bulletin of Namangan State University

Abstract

Reserpine in the lower of the doses used did not cause changes in behavior, but in high doses caused a loss of the inversion reflex in frogs. Anabazamine or lupinin administered 1 or 2 hours before reserpine caused a loss of the inversion reflex. The action of alkaloids persisted only for 1 hour after administration of reserpine. These effects of alkaloids have been shown by the tests of 5-oxytriptophane and apomorphine. Imipramine significantly potentiated the effect of reserpine within 4 hours.

First Page

43

Last Page

49

References

1. Lapin I.P., Oksenkrug G.F.,Osipova S.V.,Uskova N.V. Usilenie tritsiklicheskimi antidepressantami tormozyashego vliyaniya apomorfina na refleks perevorachivaniya u lyagushki. Farmakol i toksikol. 1984,4,407-410 2. Lapin I.P., Oksenkrug G.F., Rijov I.V., Nikoforov V.A. potensirovanie deystviya rezerpina na lyagushke kak xarakterniy effekt antidepressantov. Farmakol i toksikol. 1986,2,144-147 3. Oksenkrug G.F., Vliyanie protiksena i blizkix k nemu soedeneniy na pogloshenie serotonina trombotsitami cheloveka. Byull. eksper. biol. i med. 1995,8,74-77. 4. Oksenkrug G.F., Lapin I.P. differensirovanie vtorichnix i tretichnix tritsiklicheskix antidepressantov na lyagushke. Byull. eksper. biol. i med. 1992,7,64-65. 5. Oksenkrug G.F., Osipova S.V., Uskova N.V. Sinergizm demetilimipramina s rezerpinov i 5-oksitriptofanom. Uroven serotonina i adrenalina v mozgu lyagushek v sopostavlenii s izmeneniyami povedeniya. Serotoninergicheskie protsessi v deystvii psixotropnix sredstv Tr. Leningr. nauchno-issledovat. Psixonevrol in-ta im. V.M.Bextereva,T.53, L.,1980.47-58.

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