Scientific Bulletin of Namangan State University


In male mice of two strains SHR and C57BL/6, pretreatment with bicuculline (1 mg/kg, s.c.), an antagonist of GABA-A receptors,potentially the convulsant effect of pentylenetetrazole (40mg/kg,ip.) and caffeine (200mg/kg ip.) and had no effect on that of L- kynurenine (11 meg i.c.v.).Data suggest that the convulsant effect of L-kynurenine, an endogenous convulsant from neuroactive tryptophan metabolites, is not related to GABA-A receptors. Other data reported elsewhere (e.g.the antagonism of phenibut and baclofen, agonists of GABA-B receptors, to L-kynurenine) suggest that kynurenine-induced seizures are related to GABA-B receptors.

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1.Smith TA.Type A gamma-aminobutyric acid (GABAA) receptor subunits and benzodiazepine binding: significance to clinical syndromes and their treatment. Br J Biomed Sci 2001;58:111-121. 1.Lapin I.P.GAMK-ergicheskaya sistema v zashchite ot vozbuzhdayushchikh kinureninov.Voprosy med.khimii.-1997.-Т.43.-vip.6.С.548-552. 1. Lapin I.P.Farmakologicheskiye razlichiya mezhdu kinureninovymi i korazolovymi sudorogami (uchastiye GAMK-B retseptorov i dofamina).-Eksper.i klinich.farmakol.-1998. -№ 2.С.20-22. 2. Gaston M.S., Cid M.P,Salvatierra N.A.Bicuculline,a GABA-receptor antagonist, blocked HPA axis activation induced by ghrelin under an acute stress. Behav Brain Res. 2017 Mar 1;320:464-472. 3. Dede F,Karadenizli S,ozsoy oD, Eraldemir FC, Şahin D,Ates N. The Effects of Adenosinergic Modulation on Cytokine Levels in a Pentylenetetrazole-Induced Generalized Tonic-Clonic Seizure Model. Neuroimmunomodulation. 2017;24(1):54-59. 4. Souza MA, Mota BC, Gerbatin RR,Rodrigues FS,Castro M, Fighera MR, Royes LF. Antioxidant activity elicited by low dose of caffeine attenuates pentylenetetrazol-induced seizures and oxidative damage in rat. J Basic Clin Physiol Pharmacol. 2018 Jan 26;29(1):110



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