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Scientific Bulletin of Namangan State University

Abstract

Hypothyroidism in rats was caused by intraperitoneal administration of mercazolil at a dose of 1 mg per 100 g of body weight for 15 days. A decrease in the content of total triiodothyronine and a significant decrease in the content of free thyroxin are shown. The content of thyroid-stimulating hormones was 2 times higher. Against this background, a lengthening of the duration of hexenal sleep, a decrease in the content of cytochrome P-450 and b5, as well as anilinhydroxylase and amidopyrine-N-demethylase activity of microsomes were revealed. It is concluded that inhibition of the functional and metabolic activity of the monooxygenase system of the liver in hypothyroidism.

First Page

74

Last Page

78

References

1. Vismont F.I., Vismont A.F., Mikulich A.T. Ob uchastii valina krovi v mexanizmax realizatsii vliyaniya triyodtironina na protsessi detoksikatsii i termoregulyasii. // Fundamentalnie nauki – meditsine: materiali Mejdunar. nauch. konf. (Minsk, 17 maya 2013 g.). V 2 ch. CH. 1. / Nats. akad. nauk Belarusi, In-t fiziologii; redkol.: I.V Zalutskiy i dr.–Minsk: Belarus navuka, 2013.-S. 133-136. 2. Vliyanie famotidina (Kvamatela) na funksionalnoe sostoyanie sistemi biotransformatsii ksenobiotikov / I.L. Blinkov, S.V. Jelyabovskaya, M.V. Juravleva, A.I. SHatixin // Klinicheskaya farmakologiya i terapiya.–2000, №2.– S. 43-46. 3. Makarova N.G., Vasileva L.S., Garmaeva D.V. Struktura pecheni pri eksperimentalnom gipotireoze // Sibirskiy meditsinskiy jurnal.–2010.–№ 3.–S. 70-73 4. Moxort T.V., Karlovich N.V. Gipotireoz: rasprostranyonnost, klinicheskaya kartina, diagnostika, sovremennie predstavleniya o selesoobraznosti skrininga // Meditsinskie novosti.—2004.—№10.—S. 50-58. 5. Starkova N.T. Klinicheskaya endokrinologiya: rukovodstvo.M.:Meditsina, 1991. 512 s. 6. Toksiko-alimentarnaya model sirroza pecheni u kris / B.B. Osipov, A.N. Liziov, A.G. Skuratov, A.A. Prizensev // Problemi zdorovya i ekologii.–2018.–1 (55).–S. 62-66. 7. CHerkashenko O.S. Vliyanie triazavirina na aktivnost fermentov detoksikatsii // WWW.MEDLINE.RU, tom 12, Farmakologiya, may, 2011.–S. 458-463. 8. Malik R., Hodgson H. The relationship between the thyroid gland and the liver // Quart. J. Med.–2002.–Vol. 95, № 9.–P. 559-569 9. Nikolic D., van Breemen R. B. New metabolic pathways for flavanones catalyzed by rat liver microsomes // Drug. Metab. Dispos.–2004.–Vol. 32 (4).–P. 387–397. 10. Omura T., Sato R. The Carbon Monoxide-binding Pigment of Liver Microsomes. I. Evidence for Its Hemoprotein Nature // J. Biol. Chem. – 1964, v. 239.–P. 2370-2378. 11. Potentiation of thioacetamide liver injury in diabetic rats is due to induced CYP2E1 / T. Wang et al. // J. Pharmacol. and Exp. Ther.–2000.–Vol. 294, № 2.–P. 473-479. 12. Protein measurement with the Folin Phenol reagent / O.H. Lowry, N.J. Rosebrough, A.L. Farr, R.J. Randall // J. Biol. Chem.–1951, v. 193.–P. 265-275. 13. The Postulated Hepatotoxic Metabolite of Methimazole Causes Mitochondrial Dysfunction and Energy Metabolism Disturbances in Liver / N. Hossein, A. Jamshidzadeh, R. Heidari, N. Abdoli, M. M. Ommati, F. Jafari, M. Zarei, B. Asadi. // Pharmaceutical Sciences.–2016.–v. 22.–P. 217-226.

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