Scientific Bulletin of Namangan State University
Abstract
The effect of a chemical modified sulfated polysaccharide in experiments on human bloodplasma in vitro on the hemostasis system was studied. The effect of in vitro compounds with various tests on APTT, prothrombin time, and thrombin were studied. In this case, the anticoagulant activity was established. The polysaccharide in the body exhibits a combined anticoagulant effect, due to which they belong to anticoagulant and antithrombin agents.
First Page
84
Last Page
92
References
1. Geerts W. Prevention of venous thromboembolism: American College of Chest Physicians evidence-based clinical practice guidelines (8th Edition)/ W. Geerts, D Bergqvist, G.F. PineoJ.A. Heit, C.M. Samama, M.R. Lassen, C.W. Colwell // Chest. - 2008. - 133 (6). - P.381S-453S. 2. Ageno W. Antithrombotic treatment of splanchnic vein thrombosis: results of an international registry / W Ageno, N Riva, S Schulman, et al. // SeminThrombHemost. - 2014.- Feb;40(l). - P.99-105. 3. Molteni M. Warfarin and atrial fibrillation: from ideal to real the warfarin affaire/ M. Molteni, C. Cimminiello // Thromb J. - 2014. - 12(1). - P.5.; VoT., 2014. 4. Vo T. Current state of anticoagulants to treat deep venous thrombosis / T. Vo, S. Vazquez, M.T. Rondina // CurrCardiol Rep. -2014. -16(3). -P.463. 5. Verhaeghe R., DeMoerloose P., Eikenboom J.C. et al. Genetic and asquired risk factors of venous thromboembolism. In: Pulmonary Vascular Pathology: A Clinical Update. Eds. M. Demedts, M. Delcroix, R. Verhaeghe, G.M. Verleden. EurRespSoc 2004. –С. 9. 6. Wang Z.M., Li L., Zheng B.S., Normakhamatov N., GuoS.Y. Preparation and anticoagulation activity of sodium cellulose sulfate // Int. J. Biol. Macromol. 2007. Vol.41 (2). -P. 376-382. 7. Huynh R., Chaubet F., Jozefonvicz J. Anticoagulant properties of dextranmethylcarboxylatebenzylamide sulfate (DMCBSu); a new generation of bioactive functionalized dextran // Carbohydr. Res. 2001. Vol. 332. -P. 75-83. 10. 8. Mahner C., Lechner M. D., Nordmeier E. Synthesis and characterization of dextran and pullulan sulphate // Carbohydr. Res. 2001. Vol. 331. -P. 203-208.
Erratum
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Recommended Citation
Khoshimov, Nоzimjon Numonovich; Nasirov, Kobil Erkinovich; Muhitdinov, Bakhtiyor Ikramovich; and Azizov, Vaydulla Gaffarovich.
(2019)
"RESEARCH OF ANTICOAGULANT ACTIVITY OF MODIFIED POLYSACCHARID,"
Scientific Bulletin of Namangan State University: Vol. 1
:
Iss.
10
, Article 15.
Available at:
https://uzjournals.edu.uz/namdu/vol1/iss10/15