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Bulletin of Gulistan State University

Abstract

In this study, technical sodium carboxymethylcellulose (Na-CMC) with degree of substitution (DS) = 0.62-0.90 and a degree of polymerization (DP) = 200-600 were washed in 70% ethyl alcohol and a 2% fraction of purified Na-CMC was centrifugation at a speed of 6000 rpm for 20 minutes. A 0.1 M solution of SeO2 was added to the centrifuged Na-CMC solution at 60 ⁰C and mixed mechanically. Samples of gels, films and powders containing a solution of Na-CMC containing stabilized selenium nanoparticles synthesized by chemical reduction were taken and their physicochemical properties were studied. The size and shape of selenium nanoparticles present in the structure of Na-CMC were determined by X-ray diffraction analysis (XRD), UV spectroscopy, and atomic force microscopy (AFM) methods. Physico-chemical studies have shown that with increasing selenium oxide concentrations in CMC solutions, an increase in the size of spherical selenium nanoparticles to 9–42 nm was observed. In X-ray diffraction analysis (XRD) studies, it was observed that the crystals of selenium nanoparticles formed differential oscillations at 31.5 °, 48.5 °, 63.1 °, 64.6 °, 67 °, and 69 °. Biomedical properties of this drug were studied in collaboration with scientists of the Tashkent Medical Academy, and that the synthesized drug exhibited low toxicity to the organism was studied in experimental animals.

First Page

38

Last Page

47

References

Guo J., Skinner G.W., Harcum W.W., Barnum P.E. Pharmaceutical applications of naturally occurring water soluble polymers, PSTT. 1, 1998, pp. 254-261.

Bozena Hosnedlova, Nanoselenium and its nanomedicine applications: acritical review. International Journal of Nanomedicine 2018:13, pp. 2107–2128.

Reshetnyak L.A., Selenium and human health (literature review), L.A. Reshetnyak, E.O. Parfenova, Ecology of Orya. - 2000. - No. 59. pp. 20-25.

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