Bulletin of Gulistan State University


In the following research it was determined that extracts (100 μg/ml) of fruit and peel of some local varieties («Qora Qayim», «Qizil anor», «Oq dona/tuyatish», «Achchiq dona») of pomegranate (Punica granatum L.) grown in the Syrdarya region of Mirzachul oasis of the Republic of Uzbekistan, in vitro have an inhibitory effect on the functional activity of the megacanal (mitochondrial permeability transition pore – mPTP) associated with Ca2+ in the mitochondria of the rat liver. It was determined that under the influence of Ca2+ (50 μm) extracts (100 μg/ml) of pomegranate fruit «Qora Qayim», «Qizil anor», «Oq dona/tuyatish», «Achchiq dona» in comparison with the control decelerates the wet mitochondria on 64,3±4,8; 78,5±6,4; 74,2±5,3 and 85,6±4,5%, respectively, during the next series of experiments, it was determined that the peel extracts (100 μg/ml) of pomegranate varieties «Qora Qayim», «Qizil anor», «Oq dona/tuyatish», «Achchiq dona» reduce this indicator in comparison with control to 76,8±5,2; 53,4±3,8; 84,2±6,5 and 70,4±5,5% respectively. The results obtained in the future can be used to clarify the mechanisms of pharmacological influence of extracts of pomegranate (Punica granatum L.) fruit and peel.

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