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Problems and perspectives in pharmaceutics and drug discovery

Abstract

The acute toxicity of the herb of Phlomis thapsoides, grown on the territory of Uzbekistan, was studied. Acute toxicity studies were conducted according to a conventional method on white mongrel mice (both sexes). From the herb was prepared infusion, which was administered orally, at five dose levels. As a result, it was found that the infusion of Phlomis thapsoides herbs is highly harmless, since LD50> 6000 mg / kg - the preparation belongs to the fifth toxicity class (almost non-toxic). The presence in the infusion of potential sedative and neurotropic activity was also established.

First Page

76

Last Page

79

References

1. http://lektrava.ru/encyclopedia/zopnik-kolyuchiy/. 2. Rukovodstvo po eksperimentalnomu (doklinicheskomu) izucheniyu novix farmakologicheskix veshestv / [pod obsh. red. R. U. Xabrieva]. - 2-e izd., pererab. i dop. - M.: OAO "Izd-vo "Meditsina", 2005. - 832 s. 3. Rukovodstvo po provedeniyu doklinicheskix issledovaniy lekarstvennix sredstv. Chast pervaya / [pod red. A.N. Mironova]. - M.: Grif i K, 2012. - 944 s. 4. Doklinicheskie issledovaniya lekarstvennix sredstv (metodicheskie rekomendatsii). / [pod red. A.V. Stefanova]. - Kiev: Avitsena, 2002. - 568 s. 5. GOST 12.1.007-76. Sistema standartov bezopasnosti truda. Vrednie veshestva. Klassifikatsiya i obshie trebovaniya bezopasnosti. - Moskva: FGUP "Standartinform", 2007. - 7 s.

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