Problems and Perspectives in Pharmaceutics and Drug Discovery


By experiments on studying of influence of preparation К-26 on synthesis DNA and RNA, an expres-sion of MDR2 drug resistance gene and p53 gene it is established, that in tumor cells the preparation sup-presses synthesis DNA and RNA than etoposide. Low level of an expression MDR2 gene (within 15 %) in comparison with for the most expression of this gene under influence etoposide is observed. The gene ex-pression р53 considerably increases to 80 % (at etoposide to 55 %), that defines big ability К-26 to induce tumor apoptosis. Higher level of an expression of gene MDR2 in spleen cages (55 %) under the influence of prepara-tion К-26 that reflects the big sensitivity of a tumor to a new preparation, than a susceptibility of normal body is simultaneously observed. Also in spleen cells the smaller expression of p53 gene caused К-26 in comparison with etoposide is observed, that specifies in less destructive influence К-26 on a spleen. There-upon, there are strong reasons to study preparation К-26 overcoming resistance for the subsequent influ-ence on a kidney cancer

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