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Problems and perspectives in pharmaceutics and drug discovery

Abstract

Presents data on the subchronic toxicity of the new domestic cholagogue "Triflos". Studies have shown that the examined cholagogue collection with repeated intragastric administration for 28 days in a thera-peutic dose, at the maximum daily dose and 20 times higher than the therapeutic dose, does not cause a violation of the functional state of the main organs and body systems.

First Page

100

Last Page

105

References

1. Pravila doklinicheskoy otsenki bezopasnosti farmakologicheskix sredstv (GLP) RD 64-126-91.Moskva, 1992.-S.78 s. 2. Klinicheskiye laboratornie issledovaniya / A.Ya. Lyubina (i dr.) // M.: “Meditsina”, 1984. – 288s. 3. Rukovodstvo po eksperimentalnomu (doklinicheskomu) izucheniyu novix farmakologicheskix veshchestv. Pod obshchey redaktsiyey chlena-korrespondenta RAMN, professora R. U. XABRIYEVA. Izdaniye vtoroye, pererabotannoye i dopolnennoye/. M.: - 2005. - M.: OAO “Izdatelstvo “Meditsina”, 2005.— s. 832.

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