The aim is to optimize the conditions for the synthesis of 3(H)-quinazolin-4-one by the method of mathematical modeling to develop a technology for producing the substance of a new domestic drug used in the treatment of farm animals from helminths. In mathematical modeling, the method of a small number of squares was used. Analytical dependences of the product yield on temperature, reaction time, and molar ratios of the starting materials were determined. A system of linear equations has been compiled. The system of linear equations was performed by the matrix method (A, B, C).The average reaction rate was determined. Based on the results obtained, a 3(H)-quinazolin-4-one diagram using the Maple 18 program and an icon diagram of the reaction duration, temperature, and reaction rate are shown. Based on the results of mathematical modeling, a highly efficient technological scheme for obtaining 3(H)-quinazolin-4-one has been developed. Based on this technology, compound 3(H)-quinazolin-4-one was synthesized in quantitative products at the Institute of Plant Chemistry, at a pilot production plant.The results obtained confirmed the found optimal conditions
Mirjalol, ZIYADULLAYEV; Rikhsibay, KARIMOV; Asqar, ABDURAZAKOV; and Asqar, PARMONOV
"MATHEMATICAL MODELING OF THE 3(Н)-QUINAZOLIN-4-ONЕ
CHEMISTRY AND CHEMICAL ENGINEERING: Vol. 2020
, Article 9.
Available at: https://uzjournals.edu.uz/cce/vol2020/iss4/9