Considering that many derivatives of bis carbamates have different biological activity, it was intuitive to produce a targeted synthesis of new derivatives of bis carbamates by the interaction of hexamethylene diisocyanate with 3,5-diode-4-hydroxybenzoic acid and 2,4,6-triiodophenol (1: 2 mol, respectively) in freshly distilled dry pyridine at 95-110 оC for 6 hours, the corresponding derivatives were obtained - methylene bis carbamates. Experimental studies have been conducted to identify the acute toxicity and radiopaque properties of the synthesized new N, -hexamethylene bis (2,6-diode-4-carboxyphenylcarbamate).
Ubaydulla, Baltabaev; Abdukahhor, Djuraev; Jahongir, Abduvakilov; and Matluba, Abdullaeva
"Radiopaque activity of iodine containing methylene-bis-carbamate,"
CHEMISTRY AND CHEMICAL ENGINEERING: Vol. 2020
, Article 7.
Available at: https://uzjournals.edu.uz/cce/vol2020/iss1/7