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CHEMISTRY AND CHEMICAL ENGINEERING

CHEMISTRY AND CHEMICAL ENGINEERING

Abstract

Considering that many derivatives of bis carbamates have different biological activity, it was intuitive to produce a targeted synthesis of new derivatives of bis carbamates by the interaction of hexamethylene diisocyanate with 3,5-diode-4-hydroxybenzoic acid and 2,4,6-triiodophenol (1: 2 mol, respectively) in freshly distilled dry pyridine at 95-110 оC for 6 hours, the corresponding derivatives were obtained - methylene bis carbamates. Experimental studies have been conducted to identify the acute toxicity and radiopaque properties of the synthesized new N, -hexamethylene bis (2,6-diode-4-carboxyphenylcarbamate).

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