The synthesis of acetylene alcohol 1,3-diphenyl propin-2-ol-1, which has several reaction centers in the molecule, is studied. This product was obtained for the first time from a representative of aromatic hydrocarbons of benzaldehyde with phenylacetylene based on an alkynylation reaction in the presence of stereoselective catalysts - ZnEt2/Ti(OiPr)4/PhMe and Sn(OTf)2/NEt3/MeCN. The influence of the activity, stability, and selectivity of the selected catalysts on the yield of products, as well as, the rate of the main reactions, along with side reactions was analyzed. The optimal conditions for the alkynylation reaction and the selectivity of the process are determined. The main and by-products formed in this process are identified. Suggestions are made for the formation of unstable intermediate compounds - carbcations, carbanions, radicals, as well as, active complexes of reactions and catalytic modifications formed in the transition state. A number of efficiencies have been developed for catalysts for the enantoselective alkynylation reaction.



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